Harbut MB - Search Results

1

Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.

Liu R, Lyu X, Batt SM, Hsu MH, Harbut MB, Vilchèze C, Cheng B, Ajayi K, Yang B, Yang Y, Guo H, Lin C, Gan F, Wang C, Franzblau SG, Jacobs WR Jr, Besra GS, Johnson EF, Petrassi M, Chatterjee AK, Fütterer K, Wang F. Liu R, et al. Among authors: harbut mb. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13011-13015. doi: 10.1002/anie.201707324. Epub 2017 Sep 7. Angew Chem Int Ed Engl. 2017. PMID: 28815830 Free PMC article.

2

Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity.

Harbut MB, Yang B, Liu R, Yano T, Vilchèze C, Cheng B, Lockner J, Guo H, Yu C, Franzblau SG, Petrassi HM, Jacobs WR Jr, Rubin H, Chatterjee AK, Wang F. Harbut MB, et al. Angew Chem Int Ed Engl. 2018 Mar 19;57(13):3478-3482. doi: 10.1002/anie.201800260. Epub 2018 Feb 22. Angew Chem Int Ed Engl. 2018. PMID: 29388301 Free PMC article.

3

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis.

Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR Jr, Schultz PG, Wang F. Harbut MB, et al. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4453-8. doi: 10.1073/pnas.1504022112. Epub 2015 Mar 23. Proc Natl Acad Sci U S A. 2015. PMID: 25831516 Free PMC article.

4

Selective BET bromodomain inhibition as an antifungal therapeutic strategy.

Mietton F, Ferri E, Champleboux M, Zala N, Maubon D, Zhou Y, Harbut M, Spittler D, Garnaud C, Courçon M, Chauvel M, d'Enfert C, Kashemirov BA, Hull M, Cornet M, McKenna CE, Govin J, Petosa C. Mietton F, et al. Nat Commun. 2017 May 18;8:15482. doi: 10.1038/ncomms15482. Nat Commun. 2017. PMID: 28516956 Free PMC article.

5

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.

Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC. Harbut MB, et al. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21486-91. doi: 10.1073/pnas.1216016110. Epub 2012 Dec 11. Proc Natl Acad Sci U S A. 2012. PMID: 23236186 Free PMC article.

6

Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.

Chandramohanadas R, Davis PH, Beiting DP, Harbut MB, Darling C, Velmourougane G, Lee MY, Greer PA, Roos DS, Greenbaum DC. Chandramohanadas R, et al. Among authors: harbut mb. Science. 2009 May 8;324(5928):794-7. doi: 10.1126/science.1171085. Epub 2009 Apr 2. Science. 2009. PMID: 19342550 Free PMC article.

7

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.

Harbut MB, Velmourougane G, Dalal S, Reiss G, Whisstock JC, Onder O, Brisson D, McGowan S, Klemba M, Greenbaum DC. Harbut MB, et al. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E526-34. doi: 10.1073/pnas.1105601108. Epub 2011 Aug 15. Proc Natl Acad Sci U S A. 2011. PMID: 21844374 Free PMC article.

8

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Velmourougane G, Harbut MB, Dalal S, McGowan S, Oellig CA, Meinhardt N, Whisstock JC, Klemba M, Greenbaum DC. Velmourougane G, et al. Among authors: harbut mb. J Med Chem. 2011 Mar 24;54(6):1655-66. doi: 10.1021/jm101227t. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366301 Free PMC article.

9

Development of bestatin-based activity-based probes for metallo-aminopeptidases.

Harbut MB, Velmourougane G, Reiss G, Chandramohanadas R, Greenbaum DC. Harbut MB, et al. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5932-6. doi: 10.1016/j.bmcl.2008.09.021. Epub 2008 Sep 10. Bioorg Med Chem Lett. 2008. PMID: 18823778 Free PMC article.

10

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229

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