White KA - Search Results

1

Prominent features of the amino acid mutation landscape in cancer.

Szpiech ZA, Strauli NB, White KA, Ruiz DG, Jacobson MP, Barber DL, Hernandez RD. Szpiech ZA, et al. Among authors: white ka. PLoS One. 2017 Aug 24;12(8):e0183273. doi: 10.1371/journal.pone.0183273. eCollection 2017. PLoS One. 2017. PMID: 28837668 Free PMC article.

2

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.

White KA, Ruiz DG, Szpiech ZA, Strauli NB, Hernandez RD, Jacobson MP, Barber DL. White KA, et al. Sci Signal. 2017 Sep 5;10(495):eaam9931. doi: 10.1126/scisignal.aam9931. Sci Signal. 2017. PMID: 28874603 Free PMC article.

3

Intracellular pH dynamics and charge-changing somatic mutations in cancer.

White KA, Kisor K, Barber DL. White KA, et al. Cancer Metastasis Rev. 2019 Jun;38(1-2):17-24. doi: 10.1007/s10555-019-09791-8. Cancer Metastasis Rev. 2019. PMID: 30982102 Free article. Review.

4

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance.

White KA, Grillo-Hill BK, Barber DL. White KA, et al. J Cell Sci. 2017 Feb 15;130(4):663-669. doi: 10.1242/jcs.195297. J Cell Sci. 2017. PMID: 28202602 Free PMC article. Review.

5

Low pH Facilitates Heterodimerization of Mutant Isocitrate Dehydrogenase IDH1-R132H and Promotes Production of 2-Hydroxyglutarate.

Sesanto R, Kuehn JF, Barber DL, White KA. Sesanto R, et al. Among authors: white ka. Biochemistry. 2021 Jun 29;60(25):1983-1994. doi: 10.1021/acs.biochem.1c00059. Epub 2021 Jun 18. Biochemistry. 2021. PMID: 34143606 Free PMC article.

6

Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective.

Liu Y, White KA, Barber DL. Liu Y, et al. Among authors: white ka. Front Oncol. 2020 Aug 26;10:1401. doi: 10.3389/fonc.2020.01401. eCollection 2020. Front Oncol. 2020. PMID: 32983969 Free PMC article. Review.

7

A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity.

Webb BA, White KA, Grillo-Hill BK, Schönichen A, Choi C, Barber DL. Webb BA, et al. Among authors: white ka. J Biol Chem. 2016 Nov 11;291(46):24096-24104. doi: 10.1074/jbc.M116.736215. Epub 2016 Sep 20. J Biol Chem. 2016. PMID: 27650500 Free PMC article.

8

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.

Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. Vercoulen Y, et al. Among authors: white ka. Elife. 2017 Sep 27;6:e29002. doi: 10.7554/eLife.29002. Elife. 2017. PMID: 28952923 Free PMC article.

9

β-Catenin is a pH sensor with decreased stability at higher intracellular pH.

White KA, Grillo-Hill BK, Esquivel M, Peralta J, Bui VN, Chire I, Barber DL. White KA, et al. J Cell Biol. 2018 Nov 5;217(11):3965-3976. doi: 10.1083/jcb.201712041. Epub 2018 Oct 12. J Cell Biol. 2018. PMID: 30315137 Free PMC article.

10

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.

Luna LA, Lesecq Z, White KA, Hoang A, Scott DA, Zagnitko O, Bobkov AA, Barber DL, Schiffer JM, Isom DG, Sohl CD. Luna LA, et al. Among authors: white ka. Biochem J. 2020 Aug 28;477(16):2999-3018. doi: 10.1042/BCJ20200311. Biochem J. 2020. PMID: 32729927 Free PMC article.

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