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Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.
Hulme H, Meikle LM, Strittmatter N, van der Hooft JJJ, Swales J, Bragg RA, Villar VH, Ormsby MJ, Barnes S, Brown SL, Dexter A, Kamat MT, Komen JC, Walker D, Milling S, Osterweil EK, MacDonald AS, Schofield CJ, Tardito S, Bunch J, Douce G, Edgar JM, Edrada-Ebel R, Goodwin RJA, Burchmore R, Wall DM. Hulme H, et al. Sci Adv. 2020 Mar 11;6(11):eaax6328. doi: 10.1126/sciadv.aax6328. eCollection 2020 Mar. Sci Adv. 2020. PMID: 32195337 Free PMC article.
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Graziano V, Dannhorn A, Hulme H, Williamson K, Buckley H, Karim SA, Wilson M, Lee SY, Kaistha BP, Islam S, Thaventhiran JED, Richards FM, Goodwin R, Brais R, Morton JP, Dovedi SJ, Schuller AG, Eyles J, Jodrell DI. Graziano V, et al. Among authors: hulme h. J Immunother Cancer. 2023 Aug;11(8):e006457. doi: 10.1136/jitc-2022-006457. J Immunother Cancer. 2023. PMID: 37553182 Free PMC article.
Propionic Acid Promotes the Virulent Phenotype of Crohn's Disease-Associated Adherent-Invasive Escherichia coli.
Ormsby MJ, Johnson SA, Carpena N, Meikle LM, Goldstone RJ, McIntosh A, Wessel HM, Hulme HE, McConnachie CC, Connolly JPR, Roe AJ, Hasson C, Boyd J, Fitzgerald E, Gerasimidis K, Morrison D, Hold GL, Hansen R, Walker D, Smith DGE, Wall DM. Ormsby MJ, et al. Among authors: hulme he. Cell Rep. 2020 Feb 18;30(7):2297-2305.e5. doi: 10.1016/j.celrep.2020.01.078. Cell Rep. 2020. PMID: 32075765 Free PMC article.
Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain.
Vallianatou T, Shariatgorji R, Nilsson A, Karlgren M, Hulme H, Fridjonsdottir E, Svenningsson P, Andrén PE. Vallianatou T, et al. Among authors: hulme h. ACS Chem Neurosci. 2021 May 19;12(10):1811-1823. doi: 10.1021/acschemneuro.1c00103. Epub 2021 May 3. ACS Chem Neurosci. 2021. PMID: 33939923 Free PMC article.
33 results