Wu WW - Search Results

1

Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.

Dutta S, Chang KC, Beattie KA, Sheng J, Tran PN, Wu WW, Wu M, Strauss DG, Colatsky T, Li Z. Dutta S, et al. Among authors: wu ww, wu m. Front Physiol. 2017 Aug 23;8:616. doi: 10.3389/fphys.2017.00616. eCollection 2017. Front Physiol. 2017. PMID: 28878692 Free PMC article.

2

A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel.

Li Z, Dutta S, Sheng J, Tran PN, Wu W, Colatsky T. Li Z, et al. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:233-9. doi: 10.1016/j.vascn.2016.05.005. Epub 2016 May 11. J Pharmacol Toxicol Methods. 2016. PMID: 27178106 Free PMC article.

3

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel-Drug Binding Kinetics and Multichannel Pharmacology.

Li Z, Dutta S, Sheng J, Tran PN, Wu W, Chang K, Mdluli T, Strauss DG, Colatsky T. Li Z, et al. Circ Arrhythm Electrophysiol. 2017 Feb;10(2):e004628. doi: 10.1161/CIRCEP.116.004628. Circ Arrhythm Electrophysiol. 2017. PMID: 28202629

4

Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity.

Sheng J, Tran PN, Li Z, Dutta S, Chang K, Colatsky T, Wu WW. Sheng J, et al. Among authors: wu ww. J Pharmacol Toxicol Methods. 2017 Nov-Dec;88(Pt 2):109-122. doi: 10.1016/j.vascn.2017.08.006. Epub 2017 Aug 19. J Pharmacol Toxicol Methods. 2017. PMID: 28830713

5

Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment.

Chang KC, Dutta S, Mirams GR, Beattie KA, Sheng J, Tran PN, Wu M, Wu WW, Colatsky T, Strauss DG, Li Z. Chang KC, et al. Among authors: wu ww, wu m. Front Physiol. 2017 Nov 21;8:917. doi: 10.3389/fphys.2017.00917. eCollection 2017. Front Physiol. 2017. PMID: 29209226 Free PMC article.

6

Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.

Dutta S, Chang KC, Beattie KA, Sheng J, Tran PN, Wu WW, Wu M, Strauss DG, Colatsky T, Li Z. Dutta S, et al. Among authors: wu ww, wu m. Front Physiol. 2017 Dec 6;8:1025. doi: 10.3389/fphys.2017.01025. eCollection 2017. Front Physiol. 2017. PMID: 29230183 Free PMC article.

7

Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative.

Li Z, Ridder BJ, Han X, Wu WW, Sheng J, Tran PN, Wu M, Randolph A, Johnstone RH, Mirams GR, Kuryshev Y, Kramer J, Wu C, Crumb WJ Jr, Strauss DG. Li Z, et al. Among authors: wu ww, wu c, wu m. Clin Pharmacol Ther. 2019 Feb;105(2):466-475. doi: 10.1002/cpt.1184. Epub 2018 Aug 27. Clin Pharmacol Ther. 2019. PMID: 30151907 Free PMC article.

8

Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting.

Strauss DG, Gintant G, Li Z, Wu W, Blinova K, Vicente J, Turner JR, Sager PT. Strauss DG, et al. Ther Innov Regul Sci. 2019 Jul;53(4):519-525. doi: 10.1177/2168479018795117. Epub 2018 Aug 29. Ther Innov Regul Sci. 2019. PMID: 30157676

9

Drug potency on inhibiting late Na⁺ current is sensitive to gating modifier and current region where drug effects were measured.

Wu M, Tran PN, Sheng J, Randolph AL, Wu WW. Wu M, et al. Among authors: wu ww. J Pharmacol Toxicol Methods. 2019 Nov-Dec;100:106605. doi: 10.1016/j.vascn.2019.106605. Epub 2019 Jun 27. J Pharmacol Toxicol Methods. 2019. PMID: 31255744 Free article.

10

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.

Ridder BJ, Leishman DJ, Bridgland-Taylor M, Samieegohar M, Han X, Wu WW, Randolph A, Tran P, Sheng J, Danker T, Lindqvist A, Konrad D, Hebeisen S, Polonchuk L, Gissinger E, Renganathan M, Koci B, Wei H, Fan J, Levesque P, Kwagh J, Imredy J, Zhai J, Rogers M, Humphries E, Kirby R, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Himmel H, Mirams GR, Strauss DG, Bardenet R, Li Z. Ridder BJ, et al. Among authors: wu ww, wu c. Toxicol Appl Pharmacol. 2020 May 1;394:114961. doi: 10.1016/j.taap.2020.114961. Epub 2020 Mar 21. Toxicol Appl Pharmacol. 2020. PMID: 32209365 Free PMC article.

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