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A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.
Chang D, Nalls MA, Hallgrímsdóttir IB, Hunkapiller J, van der Brug M, Cai F; International Parkinson's Disease Genomics Consortium; 23andMe Research Team; Kerchner GA, Ayalon G, Bingol B, Sheng M, Hinds D, Behrens TW, Singleton AB, Bhangale TR, Graham RR. Chang D, et al. Among authors: cai f. Nat Genet. 2017 Oct;49(10):1511-1516. doi: 10.1038/ng.3955. Epub 2017 Sep 11. Nat Genet. 2017. PMID: 28892059 Free PMC article.
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, Burdick DJ, Gunzner-Toste J, Chen H, Liu X, Estrada AA, Sweeney ZK, Scearce-Levie K, Moffat JG, Kirkpatrick DS, Zhu H. Sheng Z, et al. Among authors: cai f. Sci Transl Med. 2012 Dec 12;4(164):164ra161. doi: 10.1126/scitranslmed.3004485. Sci Transl Med. 2012. PMID: 23241745
Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses.
Srinivasan K, Friedman BA, Larson JL, Lauffer BE, Goldstein LD, Appling LL, Borneo J, Poon C, Ho T, Cai F, Steiner P, van der Brug MP, Modrusan Z, Kaminker JS, Hansen DV. Srinivasan K, et al. Among authors: cai f. Nat Commun. 2016 Apr 21;7:11295. doi: 10.1038/ncomms11295. Nat Commun. 2016. PMID: 27097852 Free PMC article.
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ; UCSF COMET Consortium; Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. Hackney JA, et al. Among authors: cai f. iScience. 2023 Sep 1;26(10):107813. doi: 10.1016/j.isci.2023.107813. eCollection 2023 Oct 20. iScience. 2023. PMID: 37810211 Free PMC article.
Integrated systems modeling of severe asthma: Exploration of IL-33/ST2 antagonism.
Gadkar K, Feigelman J, Sukumaran S, Rodrigo MC, Staton T, Cai F, Bauer RN, Choy DF, Stokes CL, Scheerens H, Ramanujan S. Gadkar K, et al. Among authors: cai f. CPT Pharmacometrics Syst Pharmacol. 2022 Sep;11(9):1268-1277. doi: 10.1002/psp4.12842. Epub 2022 Jul 20. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35857704 Free PMC article.
Interleukin-13 in Asthma and Other Eosinophilic Disorders.
Doran E, Cai F, Holweg CTJ, Wong K, Brumm J, Arron JR. Doran E, et al. Among authors: cai f. Front Med (Lausanne). 2017 Sep 19;4:139. doi: 10.3389/fmed.2017.00139. eCollection 2017. Front Med (Lausanne). 2017. PMID: 29034234 Free PMC article.
Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial.
Braithwaite IE, Cai F, Tom JA, Galanter JM, Owen RP, Zhu R, Williams M, McGregor AG, Eliahu A, Durk MR, Dengler HS, Zak M, Kenny JR, Wilson ME, Beasley R, Chen H. Braithwaite IE, et al. Among authors: cai f. J Allergy Clin Immunol. 2021 Sep;148(3):783-789. doi: 10.1016/j.jaci.2021.02.042. Epub 2021 Mar 17. J Allergy Clin Immunol. 2021. PMID: 33744327 Free article. Clinical Trial.
1,580 results