Holyoak T - Search Results

1

Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella.

Eckhard U, Bandukwala H, Mansfield MJ, Marino G, Cheng J, Wallace I, Holyoak T, Charles TC, Austin J, Overall CM, Doxey AC. Eckhard U, et al. Among authors: holyoak t. Nat Commun. 2017 Sep 12;8(1):521. doi: 10.1038/s41467-017-00599-0. Nat Commun. 2017. PMID: 28900095 Free PMC article.

2

A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.

Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL. Xia Z, et al. Among authors: holyoak t. PLoS One. 2010 Nov 30;5(11):e14169. doi: 10.1371/journal.pone.0014169. PLoS One. 2010. PMID: 21152065 Free PMC article.

3

2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor.

Holyoak T, Wilson MA, Fenn TD, Kettner CA, Petsko GA, Fuller RS, Ringe D. Holyoak T, et al. Biochemistry. 2003 Jun 10;42(22):6709-18. doi: 10.1021/bi034434t. Biochemistry. 2003. PMID: 12779325

4

Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals.

Holyoak T, Fenn TD, Wilson MA, Moulin AG, Ringe D, Petsko GA. Holyoak T, et al. Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2356-8. doi: 10.1107/s0907444903021784. Epub 2003 Nov 27. Acta Crystallogr D Biol Crystallogr. 2003. PMID: 14646118

5

Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases.

Holyoak T, Kettner CA, Petsko GA, Fuller RS, Ringe D. Holyoak T, et al. Biochemistry. 2004 Mar 9;43(9):2412-21. doi: 10.1021/bi035849h. Biochemistry. 2004. PMID: 14992578

6

Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase.

Fenn TD, Holyoak T, Stamper GF, Ringe D. Fenn TD, et al. Among authors: holyoak t. Biochemistry. 2005 Apr 12;44(14):5317-27. doi: 10.1021/bi047842l. Biochemistry. 2005. PMID: 15807525

7

The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease.

Tran N, Dasari S, Barwell SAE, McLeod MJ, Kalyaanamoorthy S, Holyoak T, Ganesan A. Tran N, et al. Among authors: holyoak t. Nat Commun. 2023 Sep 12;14(1):5625. doi: 10.1038/s41467-023-40023-4. Nat Commun. 2023. PMID: 37699927 Free PMC article.

8

Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease.

Wang Z, Rahkola J, Redzic JS, Chi YC, Tran N, Holyoak T, Zheng H, Janoff E, Eisenmesser E. Wang Z, et al. Among authors: holyoak t. Nat Commun. 2020 Nov 27;11(1):6063. doi: 10.1038/s41467-020-19887-3. Nat Commun. 2020. PMID: 33247098 Free PMC article.

9

Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase.

Johnson TA, Mcleod MJ, Holyoak T. Johnson TA, et al. Among authors: holyoak t. Biochemistry. 2016 Jan 26;55(3):575-87. doi: 10.1021/acs.biochem.5b01215. Epub 2016 Jan 13. Biochemistry. 2016. PMID: 26709450

10

Exploring the limits of the usefulness of mutagenesis in studies of allosteric mechanisms.

Tang Q, Alontaga AY, Holyoak T, Fenton AW. Tang Q, et al. Among authors: holyoak t. Hum Mutat. 2017 Sep;38(9):1144-1154. doi: 10.1002/humu.23239. Epub 2017 May 23. Hum Mutat. 2017. PMID: 28459139 Free PMC article.

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