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Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.
Kanow MA, Giarmarco MM, Jankowski CS, Tsantilas K, Engel AL, Du J, Linton JD, Farnsworth CC, Sloat SR, Rountree A, Sweet IR, Lindsay KJ, Parker ED, Brockerhoff SE, Sadilek M, Chao JR, Hurley JB. Kanow MA, et al. Among authors: sweet ir. Elife. 2017 Sep 13;6:e28899. doi: 10.7554/eLife.28899. Elife. 2017. PMID: 28901286 Free PMC article.
A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer.
Uo T, Ojo KK, Sprenger CC, Epilepsia KS, Perera BGK, Damodarasamy M, Sun S, Kim S, Hogan HH, Hulverson MA, Choi R, Whitman GR, Barrett LK, Michaels SA, Xu LH, Sun VL, Arnold SLM, Pang HJ, Nguyen MM, Vigil ABG, Kamat V, Sullivan LB, Sweet IR, Vidadala R, Maly DJ, Van Voorhis WC, Plymate SR. Uo T, et al. Among authors: sweet ir. bioRxiv [Preprint]. 2024 Feb 13:2023.07.01.547355. doi: 10.1101/2023.07.01.547355. bioRxiv. 2024. Update in: Mol Cancer Ther. 2024 Jul 2;23(7):973-994. doi: 10.1158/1535-7163.MCT-23-0540 PMID: 37461469 Free PMC article. Updated. Preprint.
Flow of energy in the outer retina in darkness and in light.
Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns GW, Lindsay K, Wei J, Chertov AO, Peters TA, Caffe R, Pluk H, Seeliger MW, Tanimoto N, Fong K, Bolton L, Kuok DL, Sweet IR, Bartoletti TM, Radu RA, Travis GH, Zagotta WN, Townes-Anderson E, Parker E, Van der Zee CE, Sampath AP, Sokolov M, Thoreson WB, Hurley JB. Linton JD, et al. Among authors: sweet ir. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8599-604. doi: 10.1073/pnas.1002471107. Epub 2010 May 5. Proc Natl Acad Sci U S A. 2010. PMID: 20445106 Free PMC article.
Roles of glucose in photoreceptor survival.
Chertov AO, Holzhausen L, Kuok IT, Couron D, Parker E, Linton JD, Sadilek M, Sweet IR, Hurley JB. Chertov AO, et al. Among authors: sweet ir. J Biol Chem. 2011 Oct 7;286(40):34700-11. doi: 10.1074/jbc.M111.279752. Epub 2011 Aug 12. J Biol Chem. 2011. PMID: 21840997 Free PMC article.
Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes.
Rountree AM, Reed BJ, Cummings BP, Jung SR, Stanhope KL, Graham JL, Griffen SC, Hull RL, Havel PJ, Sweet IR. Rountree AM, et al. Among authors: sweet ir. Diabetologia. 2013 Apr;56(4):803-13. doi: 10.1007/s00125-012-2808-6. Epub 2013 Feb 13. Diabetologia. 2013. PMID: 23404441 Free PMC article.
Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina.
Du J, Cleghorn WM, Contreras L, Lindsay K, Rountree AM, Chertov AO, Turner SJ, Sahaboglu A, Linton J, Sadilek M, Satrústegui J, Sweet IR, Paquet-Durand F, Hurley JB. Du J, et al. Among authors: sweet ir. J Biol Chem. 2013 Dec 13;288(50):36129-40. doi: 10.1074/jbc.M113.507285. Epub 2013 Nov 1. J Biol Chem. 2013. PMID: 24187136 Free PMC article.
Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina.
Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satrústegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB. Du J, et al. Among authors: sweet ir. J Biol Chem. 2016 Feb 26;291(9):4698-710. doi: 10.1074/jbc.M115.698985. Epub 2015 Dec 16. J Biol Chem. 2016. PMID: 26677218 Free PMC article.
Real-time imaging of intracellular hydrogen peroxide in pancreatic islets.
Neal A, Rountree A, Kernan K, Van Yserloo B, Zhang H, Reed BJ, Osborne W, Wang W, Sweet IR. Neal A, et al. Among authors: sweet ir. Biochem J. 2016 Dec 1;473(23):4443-4456. doi: 10.1042/BCJ20160481. Epub 2016 Oct 11. Biochem J. 2016. PMID: 27729543 Free PMC article.
93 results