Chen X - Search Results

1

The Chromatin Structure Differentially Impacts High-Specificity CRISPR-Cas9 Nuclease Strategies.

Chen X, Liu J, Janssen JM, Gonçalves MAFV. Chen X, et al. Mol Ther Nucleic Acids. 2017 Sep 15;8:558-563. doi: 10.1016/j.omtn.2017.08.005. Epub 2017 Aug 12. Mol Ther Nucleic Acids. 2017. PMID: 28918055 Free PMC article. No abstract available.

2

Probing the impact of chromatin conformation on genome editing tools.

Chen X, Rinsma M, Janssen JM, Liu J, Maggio I, Gonçalves MA. Chen X, et al. Nucleic Acids Res. 2016 Jul 27;44(13):6482-92. doi: 10.1093/nar/gkw524. Epub 2016 Jun 8. Nucleic Acids Res. 2016. PMID: 27280977 Free PMC article.

3

The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events.

Janssen JM, Chen X, Liu J, Gonçalves MAFV. Janssen JM, et al. Among authors: chen x. Mol Ther Nucleic Acids. 2019 Jun 7;16:141-154. doi: 10.1016/j.omtn.2019.02.009. Epub 2019 Feb 20. Mol Ther Nucleic Acids. 2019. PMID: 30884291 Free PMC article.

4

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking.

Chen X, Tasca F, Wang Q, Liu J, Janssen JM, Brescia MD, Bellin M, Szuhai K, Kenrick J, Frock RL, Gonçalves MAFV. Chen X, et al. Nucleic Acids Res. 2020 Jan 24;48(2):974-995. doi: 10.1093/nar/gkz1121. Nucleic Acids Res. 2020. PMID: 31799604 Free PMC article.

5

Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells.

Maggio I, Holkers M, Liu J, Janssen JM, Chen X, Gonçalves MA. Maggio I, et al. Among authors: chen x. Sci Rep. 2014 May 29;4:5105. doi: 10.1038/srep05105. Sci Rep. 2014. PMID: 24870050 Free PMC article.

6

Engineered Viruses as Genome Editing Devices.

Chen X, Gonçalves MA. Chen X, et al. Mol Ther. 2016 Mar;24(3):447-57. doi: 10.1038/mt.2015.164. Epub 2015 Sep 4. Mol Ther. 2016. PMID: 26336974 Free PMC article. Review.

7

Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations.

Maggio I, Stefanucci L, Janssen JM, Liu J, Chen X, Mouly V, Gonçalves MA. Maggio I, et al. Among authors: chen x. Nucleic Acids Res. 2016 Feb 18;44(3):1449-70. doi: 10.1093/nar/gkv1540. Epub 2016 Jan 13. Nucleic Acids Res. 2016. PMID: 26762977 Free PMC article.

8

Adenoviral vectors encoding CRISPR/Cas9 multiplexes rescue dystrophin synthesis in unselected populations of DMD muscle cells.

Maggio I, Liu J, Janssen JM, Chen X, Gonçalves MA. Maggio I, et al. Among authors: chen x. Sci Rep. 2016 Nov 15;6:37051. doi: 10.1038/srep37051. Sci Rep. 2016. PMID: 27845387 Free PMC article.

9

In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting.

Chen X, Janssen JM, Liu J, Maggio I, 't Jong AEJ, Mikkers HMM, Gonçalves MAFV. Chen X, et al. Nat Commun. 2017 Sep 22;8(1):657. doi: 10.1038/s41467-017-00687-1. Nat Commun. 2017. PMID: 28939824 Free PMC article.

10

DNA, RNA, and Protein Tools for Editing the Genetic Information in Human Cells.

Chen X, Gonçalves MAFV. Chen X, et al. iScience. 2018 Aug 31;6:247-263. doi: 10.1016/j.isci.2018.08.001. Epub 2018 Aug 4. iScience. 2018. PMID: 30240615 Free PMC article. Review.

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