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Leukocyte telomere length is associated with high-risk plaques on virtual histology intravascular ultrasound and increased proinflammatory activity.
Calvert PA, Liew TV, Gorenne I, Clarke M, Costopoulos C, Obaid DR, O'Sullivan M, Shapiro LM, McNab DC, Densem CG, Schofield PM, Braganza D, Clarke SC, Ray KK, West NE, Bennett MR. Calvert PA, et al. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2157-64. doi: 10.1161/ATVBAHA.111.229237. Epub 2011 Jun 16. Arterioscler Thromb Vasc Biol. 2011. PMID: 21680897
Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans.
Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. Yu E, et al. Circulation. 2013 Aug 13;128(7):702-12. doi: 10.1161/CIRCULATIONAHA.113.002271. Epub 2013 Jul 10. Circulation. 2013. PMID: 23841983
144 results