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Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE, Santos M, Peach ML, Kelley JA, Blumberg PM, Jelinek R, Marquez VE, Comin MJ. Garcia LC, et al. Among authors: kelsey js. Bioorg Med Chem. 2014 Jun 15;22(12):3123-40. doi: 10.1016/j.bmc.2014.04.024. Epub 2014 Apr 20. Bioorg Med Chem. 2014. PMID: 24794745 Free PMC article.
RasGRPs are targets of the anti-cancer agent ingenol-3-angelate.
Song X, Lopez-Campistrous A, Sun L, Dower NA, Kedei N, Yang J, Kelsey JS, Lewin NE, Esch TE, Blumberg PM, Stone JC. Song X, et al. Among authors: kelsey js. PLoS One. 2013 Aug 21;8(8):e72331. doi: 10.1371/journal.pone.0072331. eCollection 2013. PLoS One. 2013. PMID: 23991094 Free PMC article.
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