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d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity.
Kirkwood NK, O'Reilly M, Derudas M, Kenyon EJ, Huckvale R, van Netten SM, Ward SE, Richardson GP, Kros CJ. Kirkwood NK, et al. Among authors: kenyon ej. Front Cell Neurosci. 2017 Sep 5;11:262. doi: 10.3389/fncel.2017.00262. eCollection 2017. Front Cell Neurosci. 2017. PMID: 28928635 Free PMC article.
Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel.
O'Reilly M, Kirkwood NK, Kenyon EJ, Huckvale R, Cantillon DM, Waddell SJ, Ward SE, Richardson GP, Kros CJ, Derudas M. O'Reilly M, et al. Among authors: kenyon ej. J Med Chem. 2019 Jun 13;62(11):5312-5329. doi: 10.1021/acs.jmedchem.8b01325. Epub 2019 May 24. J Med Chem. 2019. PMID: 31083995 Free article.
Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity.
Kenyon EJ, Kirkwood NK, Kitcher SR, Goodyear RJ, Derudas M, Cantillon DM, Baxendale S, de la Vega de León A, Mahieu VN, Osgood RT, Wilson CD, Bull JC, Waddell SJ, Whitfield TT, Ward SE, Kros CJ, Richardson GP. Kenyon EJ, et al. JCI Insight. 2021 Apr 8;6(7):e145704. doi: 10.1172/jci.insight.145704. JCI Insight. 2021. PMID: 33735112 Free PMC article.
Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives.
Derudas M, O'Reilly M, Kirkwood NK, Kenyon EJ, Grimsey S, Kitcher SR, Workman S, Bull JC, Ward SE, Kros CJ, Richardson GP. Derudas M, et al. Among authors: kenyon ej. Front Cell Dev Biol. 2023 Oct 10;11:1247324. doi: 10.3389/fcell.2023.1247324. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37900280 Free PMC article.
15 results