Colby DA - Search Results

1

Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps.

Sowaileh MF, Han C, Hazlitt RA, Kim EH, John JP, Colby DA. Sowaileh MF, et al. Among authors: colby da. Tetrahedron Lett. 2017 Feb 1;58(5):396-400. doi: 10.1016/j.tetlet.2016.12.018. Epub 2016 Dec 21. Tetrahedron Lett. 2017. PMID: 28943667 Free PMC article.

2

Semisynthetic derivatives of sesquiterpene lactones by palladium-catalyzed arylation of the alpha-methylene-gamma-lactone substructure.

Han C, Barrios FJ, Riofski MV, Colby DA. Han C, et al. Among authors: colby da. J Org Chem. 2009 Sep 18;74(18):7176-9. doi: 10.1021/jo901533e. J Org Chem. 2009. PMID: 19697954

3

Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: generation of α,α-difluoroenolates for aldol reactions.

Han C, Kim EH, Colby DA. Han C, et al. Among authors: colby da. J Am Chem Soc. 2011 Apr 20;133(15):5802-5. doi: 10.1021/ja202213f. Epub 2011 Mar 28. J Am Chem Soc. 2011. PMID: 21443226

4

Exploiting the facile release of trifluoroacetate for the α-methylenation of the sterically hindered carbonyl groups on (+)-sclareolide and (-)-eburnamonine.

Riofski MV, John JP, Zheng MM, Kirshner J, Colby DA. Riofski MV, et al. Among authors: colby da. J Org Chem. 2011 May 20;76(10):3676-83. doi: 10.1021/jo102114f. Epub 2011 Apr 14. J Org Chem. 2011. PMID: 21491928

5

Synthesis of α-halo-α,α-difluoromethyl ketones by a trifluoroacetate release/halogenation protocol.

John JP, Colby DA. John JP, et al. Among authors: colby da. J Org Chem. 2011 Nov 4;76(21):9163-8. doi: 10.1021/jo2017179. Epub 2011 Oct 13. J Org Chem. 2011. PMID: 21995668 Free PMC article.

6

Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor.

Han C, Salyer AE, Kim EH, Jiang X, Jarrard RE, Powers MS, Kirchhoff AM, Salvador TK, Chester JA, Hockerman GH, Colby DA. Han C, et al. Among authors: colby da. J Med Chem. 2013 Mar 28;56(6):2456-65. doi: 10.1021/jm301805e. Epub 2013 Mar 6. J Med Chem. 2013. PMID: 23428109

7

Optimized Synthesis of a Pentafluoro-gem-diol and Conversion to a CF₂Br-Glucopyranose through Trifluoroacetate-Release and Halogenation.

Hazlitt RA, John JP, Tran QL, Colby DA. Hazlitt RA, et al. Among authors: colby da. Tetrahedron Lett. 2016 Apr 27;57(17):1906-1908. doi: 10.1016/j.tetlet.2016.03.064. Epub 2016 Mar 19. Tetrahedron Lett. 2016. PMID: 27182091 Free PMC article.

8

Generation of Magnesium Pentafluoropropen-2-olate from Hexafluoroisopropanol and Synthesis of 2,2,4,4,4-Pentafluoro-3,3-dihydroxyketones.

Hazlitt RA, Tran QL, Sowaileh MF, Colby DA. Hazlitt RA, et al. Among authors: colby da. J Org Chem. 2017 Feb 17;82(4):2231-2236. doi: 10.1021/acs.joc.6b02863. Epub 2017 Jan 31. J Org Chem. 2017. PMID: 28107014 Free PMC article.

9

Effect of Substituents and Stability of Transient Aluminum-Aminals in the Presence of Nucleophiles.

Barrios FJ, Springer BC, Hazlitt RA, Colby DA. Barrios FJ, et al. Among authors: colby da. Synthesis (Stuttg). 2015 Jan;47(2):175-180. doi: 10.1055/s-0034-1379635. Epub 2014 Dec 5. Synthesis (Stuttg). 2015. PMID: 28250502 Free PMC article.

10

Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement.

Sowaileh MF, Hazlitt RA, Colby DA. Sowaileh MF, et al. Among authors: colby da. ChemMedChem. 2017 Sep 21;12(18):1481-1490. doi: 10.1002/cmdc.201700356. Epub 2017 Sep 14. ChemMedChem. 2017. PMID: 28782186 Review.

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