Hermans AN - Search Results

1

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity.

Passini E, Britton OJ, Lu HR, Rohrbacher J, Hermans AN, Gallacher DJ, Greig RJH, Bueno-Orovio A, Rodriguez B. Passini E, et al. Among authors: hermans an. Front Physiol. 2017 Sep 12;8:668. doi: 10.3389/fphys.2017.00668. eCollection 2017. Front Physiol. 2017. PMID: 28955244 Free PMC article.

2

Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?

Lu HR, Hermans AN, Gallacher DJ. Lu HR, et al. Among authors: hermans an. Br J Pharmacol. 2012 Jun;166(4):1490-502. doi: 10.1111/j.1476-5381.2012.01880.x. Br J Pharmacol. 2012. PMID: 22300168 Free PMC article.

3

Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay.

Kopljar I, Hermans AN, Teisman A, Gallacher DJ, Lu HR. Kopljar I, et al. Among authors: hermans an. J Pharmacol Toxicol Methods. 2018 May-Jun;91:80-86. doi: 10.1016/j.vascn.2018.02.004. Epub 2018 Feb 6. J Pharmacol Toxicol Methods. 2018. PMID: 29421525

4

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.

Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ. Lu HR, et al. Among authors: hermans a. Eur J Pharmacol. 2006 Dec 28;553(1-3):229-39. doi: 10.1016/j.ejphar.2006.09.035. Epub 2006 Sep 23. Eur J Pharmacol. 2006. Corrected and republished in: Eur J Pharmacol. 2007 Dec 22;577(1-3):222-32. doi: 10.1016/j.ejphar.2007.07.070 PMID: 17054943 Corrected and republished.

5

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.

Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ. Lu HR, et al. Among authors: hermans a. Eur J Pharmacol. 2007 Dec 22;577(1-3):222-32. doi: 10.1016/j.ejphar.2007.07.070. Eur J Pharmacol. 2007. PMID: 18074444

6

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines.

Lu HR, Vlaminckx E, Hermans AN, Rohrbacher J, Van Ammel K, Towart R, Pugsley M, Gallacher DJ. Lu HR, et al. Among authors: hermans an. Br J Pharmacol. 2008 Aug;154(7):1427-38. doi: 10.1038/bjp.2008.191. Epub 2008 May 19. Br J Pharmacol. 2008. PMID: 18493243 Free PMC article.

7

Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?

Towart R, Linders JT, Hermans AN, Rohrbacher J, van der Linde HJ, Ercken M, Cik M, Roevens P, Teisman A, Gallacher DJ. Towart R, et al. Among authors: hermans an. J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):1-10. doi: 10.1016/j.vascn.2009.04.197. Epub 2009 May 9. J Pharmacol Toxicol Methods. 2009. PMID: 19439185 Review.

We have exploited this molecule to develop a ligand binding assay to detect I(Ks) blockade at an earlier stage in drug discovery, and note that several other laboratories developing new drugs have also developed higher throughput screens to detect I(Ks) blockade (e.g., [Tr …

We have exploited this molecule to develop a ligand binding assay to detect I(Ks) blockade at an earlier stage in drug discovery, and …

8

In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome.

Gallacher DJ, Van de Water A, van der Linde H, Hermans AN, Lu HR, Towart R, Volders PG. Gallacher DJ, et al. Among authors: hermans an. Cardiovasc Res. 2007 Nov 1;76(2):247-56. doi: 10.1016/j.cardiores.2007.06.019. Epub 2007 Jun 29. Cardiovasc Res. 2007. PMID: 17669388

9

In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity.

De Clerck F, Van de Water A, D'Aubioul J, Lu HR, van Rossem K, Hermans A, Van Ammel K. De Clerck F, et al. Among authors: hermans a. Fundam Clin Pharmacol. 2002 Apr;16(2):125-40. doi: 10.1046/j.1472-8206.2002.00081.x. Fundam Clin Pharmacol. 2002. PMID: 12031065 Review.

10

Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp.

Dubin AE, Nasser N, Rohrbacher J, Hermans AN, Marrannes R, Grantham C, Van Rossem K, Cik M, Chaplan SR, Gallacher D, Xu J, Guia A, Byrne NG, Mathes C. Dubin AE, et al. Among authors: hermans an. J Biomol Screen. 2005 Mar;10(2):168-81. doi: 10.1177/1087057104272295. J Biomol Screen. 2005. PMID: 15799960

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