Jain T - Search Results

1

Prediction of delayed retention of antibodies in hydrophobic interaction chromatography from sequence using machine learning.

Jain T, Boland T, Lilov A, Burnina I, Brown M, Xu Y, Vásquez M. Jain T, et al. Bioinformatics. 2017 Dec 1;33(23):3758-3766. doi: 10.1093/bioinformatics/btx519. Bioinformatics. 2017. PMID: 28961999

2

Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool.

Xu Y, Roach W, Sun T, Jain T, Prinz B, Yu TY, Torrey J, Thomas J, Bobrowicz P, Vásquez M, Wittrup KD, Krauland E. Xu Y, et al. Among authors: jain t. Protein Eng Des Sel. 2013 Oct;26(10):663-70. doi: 10.1093/protein/gzt047. Epub 2013 Sep 17. Protein Eng Des Sel. 2013. PMID: 24046438

3

High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy.

Liu Y, Caffry I, Wu J, Geng SB, Jain T, Sun T, Reid F, Cao Y, Estep P, Yu Y, Vásquez M, Tessier PM, Xu Y. Liu Y, et al. Among authors: jain t. MAbs. 2014 Mar-Apr;6(2):483-92. doi: 10.4161/mabs.27431. Epub 2013 Dec 6. MAbs. 2014. PMID: 24492294 Free PMC article.

4

An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies.

Estep P, Caffry I, Yu Y, Sun T, Cao Y, Lynaugh H, Jain T, Vásquez M, Tessier PM, Xu Y. Estep P, et al. Among authors: jain t. MAbs. 2015;7(3):553-61. doi: 10.1080/19420862.2015.1016694. MAbs. 2015. PMID: 25790175 Free PMC article.

5

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice.

Kelly RL, Sun T, Jain T, Caffry I, Yu Y, Cao Y, Lynaugh H, Brown M, Vásquez M, Wittrup KD, Xu Y. Kelly RL, et al. Among authors: jain t. MAbs. 2015;7(4):770-7. doi: 10.1080/19420862.2015.1043503. MAbs. 2015. PMID: 26047159 Free PMC article.

6

Target-independent variable region mediated effects on antibody clearance can be FcRn independent.

Kelly RL, Yu Y, Sun T, Caffry I, Lynaugh H, Brown M, Jain T, Xu Y, Wittrup KD. Kelly RL, et al. Among authors: jain t. MAbs. 2016 Oct;8(7):1269-1275. doi: 10.1080/19420862.2016.1208330. Epub 2016 Sep 9. MAbs. 2016. PMID: 27610650 Free PMC article.

7

Biophysical properties of the clinical-stage antibody landscape.

Jain T, Sun T, Durand S, Hall A, Houston NR, Nett JH, Sharkey B, Bobrowicz B, Caffry I, Yu Y, Cao Y, Lynaugh H, Brown M, Baruah H, Gray LT, Krauland EM, Xu Y, Vásquez M, Wittrup KD. Jain T, et al. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):944-949. doi: 10.1073/pnas.1616408114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096333 Free PMC article.

8

Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies.

Yang R, Jain T, Lynaugh H, Nobrega RP, Lu X, Boland T, Burnina I, Sun T, Caffry I, Brown M, Zhi X, Lilov A, Xu Y. Yang R, et al. Among authors: jain t. MAbs. 2017 May/Jun;9(4):646-653. doi: 10.1080/19420862.2017.1290753. Epub 2017 Feb 14. MAbs. 2017. PMID: 28281887 Free PMC article.

9

Deamidation and isomerization liability analysis of 131 clinical-stage antibodies.

Lu X, Nobrega RP, Lynaugh H, Jain T, Barlow K, Boland T, Sivasubramanian A, Vásquez M, Xu Y. Lu X, et al. Among authors: jain t. MAbs. 2019 Jan;11(1):45-57. doi: 10.1080/19420862.2018.1548233. Epub 2018 Dec 10. MAbs. 2019. PMID: 30526254 Free PMC article.

10

The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies.

Willis LF, Kumar A, Jain T, Caffry I, Xu Y, Radford SE, Kapur N, Vásquez M, Brockwell DJ. Willis LF, et al. Among authors: jain t. Eng Rep. 2020 May;2(5):e12147. doi: 10.1002/eng2.12147. Epub 2020 Mar 15. Eng Rep. 2020. PMID: 34901768 Free PMC article.

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