Klein WL - Search Results

1

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL. Pitt J, et al. Among authors: klein wl. Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9. Mol Biol Cell. 2017. PMID: 28963439 Free PMC article.

2

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers.

De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL. De Felice FG, et al. Among authors: klein wl. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2. Proc Natl Acad Sci U S A. 2009. PMID: 19188609 Free PMC article.

3

Aβ oligomer-induced synapse degeneration in Alzheimer's disease.

Wilcox KC, Lacor PN, Pitt J, Klein WL. Wilcox KC, et al. Among authors: klein wl. Cell Mol Neurobiol. 2011 Aug;31(6):939-48. doi: 10.1007/s10571-011-9691-4. Epub 2011 May 3. Cell Mol Neurobiol. 2011. PMID: 21538118 Free PMC article. Review.

4

Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.

Viola KL, Klein WL. Viola KL, et al. Among authors: klein wl. Acta Neuropathol. 2015 Feb;129(2):183-206. doi: 10.1007/s00401-015-1386-3. Epub 2015 Jan 22. Acta Neuropathol. 2015. PMID: 25604547 Free PMC article. Review.

5

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss.

Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Gong Y, et al. Among authors: klein wl. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10417-22. doi: 10.1073/pnas.1834302100. Epub 2003 Aug 18. Proc Natl Acad Sci U S A. 2003. PMID: 12925731 Free PMC article.

6

Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.

Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL. Lacor PN, et al. Among authors: klein wl. J Neurosci. 2007 Jan 24;27(4):796-807. doi: 10.1523/JNEUROSCI.3501-06.2007. J Neurosci. 2007. PMID: 17251419 Free PMC article.

7

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.

De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL. De Felice FG, et al. Among authors: klein wl. J Biol Chem. 2007 Apr 13;282(15):11590-601. doi: 10.1074/jbc.M607483200. Epub 2007 Feb 16. J Biol Chem. 2007. PMID: 17308309 Free article.

8

Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.

De Felice FG, Wasilewska-Sampaio AP, Barbosa AC, Gomes FC, Klein WL, Ferreira ST. De Felice FG, et al. Among authors: klein wl. Curr Alzheimer Res. 2007 Jul;4(3):263-71. doi: 10.2174/156720507781077287. Curr Alzheimer Res. 2007. PMID: 17627483 Review.

9

Amyloid beta oligomers induce impairment of neuronal insulin receptors.

Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Zhao WQ, et al. Among authors: klein wl. FASEB J. 2008 Jan;22(1):246-60. doi: 10.1096/fj.06-7703com. Epub 2007 Aug 24. FASEB J. 2008. PMID: 17720802

10

Targeting generation of antibodies specific to conformational epitopes of amyloid beta-derived neurotoxins.

Lambert MP, Velasco PT, Viola KL, Klein WL. Lambert MP, et al. Among authors: klein wl. CNS Neurol Disord Drug Targets. 2009 Mar;8(1):65-81. doi: 10.2174/187152709787601876. CNS Neurol Disord Drug Targets. 2009. PMID: 19275637 Review.

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