Curtis R - Search Results

1

Sequence composition predicts immunoglobulin superfamily members that could share the intrinsically disordered properties of antibody CH1 domains.

Hebditch M, Curtis R, Warwicker J. Hebditch M, et al. Among authors: curtis r. Sci Rep. 2017 Sep 29;7(1):12404. doi: 10.1038/s41598-017-12616-9. Sci Rep. 2017. PMID: 28963509 Free PMC article.

2

Soluble expression of proteins correlates with a lack of positively-charged surface.

Chan P, Curtis RA, Warwicker J. Chan P, et al. Sci Rep. 2013 Nov 26;3:3333. doi: 10.1038/srep03333. Sci Rep. 2013. PMID: 24276756 Free PMC article.

3

Lysine and arginine content of proteins: computational analysis suggests a new tool for solubility design.

Warwicker J, Charonis S, Curtis RA. Warwicker J, et al. Mol Pharm. 2014 Jan 6;11(1):294-303. doi: 10.1021/mp4004749. Epub 2013 Nov 27. Mol Pharm. 2014. PMID: 24283752 Free PMC article.

4

The role of electrostatics in protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R. Roberts D, et al. Among authors: curtis r. Mol Pharm. 2014 Jul 7;11(7):2475-89. doi: 10.1021/mp5002334. Epub 2014 Jun 18. Mol Pharm. 2014. PMID: 24892385

5

Specific ion and buffer effects on protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R. Roberts D, et al. Among authors: curtis r. Mol Pharm. 2015 Jan 5;12(1):179-93. doi: 10.1021/mp500533c. Epub 2014 Dec 2. Mol Pharm. 2015. PMID: 25389571

6

Proofreading of substrate structure by the Twin-Arginine Translocase is highly dependent on substrate conformational flexibility but surprisingly tolerant of surface charge and hydrophobicity changes.

Jones AS, Austerberry JI, Dajani R, Warwicker J, Curtis R, Derrick JP, Robinson C. Jones AS, et al. Among authors: curtis r. Biochim Biophys Acta. 2016 Dec;1863(12):3116-3124. doi: 10.1016/j.bbamcr.2016.09.006. Epub 2016 Sep 13. Biochim Biophys Acta. 2016. PMID: 27619192 Free article.

7

The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment.

Austerberry JI, Dajani R, Panova S, Roberts D, Golovanov AP, Pluen A, van der Walle CF, Uddin S, Warwicker J, Derrick JP, Curtis R. Austerberry JI, et al. Among authors: curtis r. Eur J Pharm Biopharm. 2017 Jun;115:18-30. doi: 10.1016/j.ejpb.2017.01.019. Epub 2017 Feb 1. Eur J Pharm Biopharm. 2017. PMID: 28161552

8

Protein-Sol: a web tool for predicting protein solubility from sequence.

Hebditch M, Carballo-Amador MA, Charonis S, Curtis R, Warwicker J. Hebditch M, et al. Among authors: curtis r. Bioinformatics. 2017 Oct 1;33(19):3098-3100. doi: 10.1093/bioinformatics/btx345. Bioinformatics. 2017. PMID: 28575391 Free PMC article.

9

Coarse-Grained Modeling of Antibodies from Small-Angle Scattering Profiles.

Corbett D, Hebditch M, Keeling R, Ke P, Ekizoglou S, Sarangapani P, Pathak J, Van Der Walle CF, Uddin S, Baldock C, Avendaño C, Curtis RA. Corbett D, et al. Among authors: curtis ra. J Phys Chem B. 2017 Sep 7;121(35):8276-8290. doi: 10.1021/acs.jpcb.7b04621. Epub 2017 Aug 25. J Phys Chem B. 2017. PMID: 28796519

10

Models for Antibody Behavior in Hydrophobic Interaction Chromatography and in Self-Association.

Hebditch M, Roche A, Curtis RA, Warwicker J. Hebditch M, et al. J Pharm Sci. 2019 Apr;108(4):1434-1441. doi: 10.1016/j.xphs.2018.11.035. Epub 2018 Nov 23. J Pharm Sci. 2019. PMID: 30476509

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