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EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA. Freed DM, et al. Among authors: leahy dj. Cell. 2017 Oct 19;171(3):683-695.e18. doi: 10.1016/j.cell.2017.09.017. Epub 2017 Oct 5. Cell. 2017. PMID: 28988771 Free PMC article.
A single ligand is sufficient to activate EGFR dimers.
Liu P, Cleveland TE 4th, Bouyain S, Byrne PO, Longo PA, Leahy DJ. Liu P, et al. Among authors: leahy dj. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10861-6. doi: 10.1073/pnas.1201114109. Epub 2012 Jun 14. Proc Natl Acad Sci U S A. 2012. PMID: 22699492 Free PMC article.
How IGF-1 activates its receptor.
Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ. Kavran JM, et al. Among authors: leahy dj. Elife. 2014 Sep 25;3:e03772. doi: 10.7554/eLife.03772. Elife. 2014. PMID: 25255214 Free PMC article.
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Qiu C, et al. Among authors: leahy dj. Structure. 2008 Mar;16(3):460-7. doi: 10.1016/j.str.2007.12.016. Structure. 2008. PMID: 18334220 Free PMC article.
113 results