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Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P. Ewart L, et al. Among authors: mettetal jt. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:65-82. doi: 10.1146/annurev-pharmtox-010617-052722. Epub 2017 Oct 13. Annu Rev Pharmacol Toxicol. 2018. PMID: 29029591 Review.
Reactive Metabolites: Current and Emerging Risk and Hazard Assessments.
Thompson RA, Isin EM, Ogese MO, Mettetal JT, Williams DP. Thompson RA, et al. Among authors: mettetal jt. Chem Res Toxicol. 2016 Apr 18;29(4):505-33. doi: 10.1021/acs.chemrestox.5b00410. Epub 2016 Jan 6. Chem Res Toxicol. 2016. PMID: 26735163 Review.
Systems pharmacology to predict drug safety in drug development.
Trame MN, Biliouris K, Lesko LJ, Mettetal JT. Trame MN, et al. Among authors: mettetal jt. Eur J Pharm Sci. 2016 Oct 30;94:93-95. doi: 10.1016/j.ejps.2016.05.027. Epub 2016 May 29. Eur J Pharm Sci. 2016. PMID: 27251780 Review.
Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.
Svensson F, Zoufir A, Mahmoud S, Afzal AM, Smit I, Giblin KA, Clements PJ, Mettetal JT, Pointon A, Harvey JS, Greene N, Williams RV, Bender A. Svensson F, et al. Among authors: mettetal jt. Chem Res Toxicol. 2018 Nov 19;31(11):1119-1127. doi: 10.1021/acs.chemrestox.8b00159. Epub 2018 Oct 17. Chem Res Toxicol. 2018. PMID: 30350600
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.
McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L. McAleer CW, et al. Among authors: mettetal jt. Sci Rep. 2019 Jul 3;9(1):9619. doi: 10.1038/s41598-019-45656-4. Sci Rep. 2019. PMID: 31270362 Free PMC article.
Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective.
Wong H, Bohnert T, Damian-Iordache V, Gibson C, Hsu CP, Krishnatry AS, Liederer BM, Lin J, Lu Q, Mettetal JT, Mudra DR, Nijsen MJMA, Schroeder P, Schuck E, Suryawanshi S, Trapa P, Tsai A, Wang H, Wu F. Wong H, et al. Among authors: mettetal jt. Drug Discov Today. 2017 Oct;22(10):1447-1459. doi: 10.1016/j.drudis.2017.04.015. Epub 2017 May 2. Drug Discov Today. 2017. PMID: 28476536 Review.
43 results