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Fragment-based approach to identify IDO1 inhibitor building blocks.
Coletti A, Camponeschi F, Albini E, Greco FA, Maione V, Custodi C, Ianni F, Grohmann U, Orabona C, Cantini F, Macchiarulo A. Coletti A, et al. Eur J Med Chem. 2017 Dec 1;141:169-177. doi: 10.1016/j.ejmech.2017.09.044. Epub 2017 Oct 3. Eur J Med Chem. 2017. PMID: 29031064 Free article.
Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry.
Coletti A, Greco FA, Dolciami D, Camaioni E, Sardella R, Pallotta MT, Volpi C, Orabona C, Grohmann U, Macchiarulo A. Coletti A, et al. Medchemcomm. 2017 May 16;8(7):1378-1392. doi: 10.1039/c7md00109f. eCollection 2017 Jul 1. Medchemcomm. 2017. PMID: 30108849 Free PMC article. Review.
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation.
Mondanelli G, Coletti A, Greco FA, Pallotta MT, Orabona C, Iacono A, Belladonna ML, Albini E, Panfili E, Fallarino F, Gargaro M, Manni G, Matino D, Carvalho A, Cunha C, Maciel P, Di Filippo M, Gaetani L, Bianchi R, Vacca C, Iamandii IM, Proietti E, Boscia F, Annunziato L, Peppelenbosch M, Puccetti P, Calabresi P, Macchiarulo A, Santambrogio L, Volpi C, Grohmann U. Mondanelli G, et al. Among authors: coletti a. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3848-3857. doi: 10.1073/pnas.1918215117. Epub 2020 Feb 5. Proc Natl Acad Sci U S A. 2020. PMID: 32024760 Free PMC article.
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity.
Serafini M, Torre E, Aprile S, Grosso ED, Gesù A, Griglio A, Colombo G, Travelli C, Paiella S, Adamo A, Orecchini E, Coletti A, Pallotta MT, Ugel S, Massarotti A, Pirali T, Fallarini S. Serafini M, et al. Among authors: coletti a. J Med Chem. 2020 Mar 26;63(6):3047-3065. doi: 10.1021/acs.jmedchem.9b01809. Epub 2020 Mar 17. J Med Chem. 2020. PMID: 32150677
117 results