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Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.
Khageh Hosseini S, Kolterer S, Steiner M, von Manstein V, Gerlach K, Trojan J, Waidmann O, Zeuzem S, Schulze JO, Hahn S, Steinhilber D, Gatterdam V, Tampé R, Biondi RM, Proschak E, Zörnig M. Khageh Hosseini S, et al. Among authors: waidmann o. Biochem Pharmacol. 2017 Dec 15;146:53-62. doi: 10.1016/j.bcp.2017.10.003. Epub 2017 Oct 13. Biochem Pharmacol. 2017. PMID: 29031818
NEMO catches the FOX.
Waidmann O, Piiper A, Zeuzem S. Waidmann O, et al. Gastroenterology. 2011 Mar;140(3):1102-3. doi: 10.1053/j.gastro.2011.01.007. Epub 2011 Jan 27. Gastroenterology. 2011. PMID: 21276766 No abstract available.
Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.
Bihrer V, Waidmann O, Friedrich-Rust M, Forestier N, Susser S, Haupenthal J, Welker M, Shi Y, Peveling-Oberhag J, Polta A, von Wagner M, Radeke HH, Sarrazin C, Trojan J, Zeuzem S, Kronenberger B, Piiper A. Bihrer V, et al. Among authors: waidmann o. PLoS One. 2011;6(10):e26971. doi: 10.1371/journal.pone.0026971. Epub 2011 Oct 31. PLoS One. 2011. PMID: 22066022 Free PMC article.
Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels.
Haupenthal J, Bihrer V, Korkusuz H, Kollmar O, Schmithals C, Kriener S, Engels K, Pleli T, Benz A, Canamero M, Longerich T, Kronenberger B, Richter S, Waidmann O, Vogl TJ, Zeuzem S, Piiper A. Haupenthal J, et al. Among authors: waidmann o. Neoplasia. 2012 May;14(5):410-9. doi: 10.1596/neo.111366. Neoplasia. 2012. PMID: 22745587 Free PMC article.
125 results