Manning BD - Search Results

1

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.

Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD. Valvezan AJ, et al. Among authors: manning bd. Cancer Cell. 2017 Nov 13;32(5):624-638.e5. doi: 10.1016/j.ccell.2017.09.013. Epub 2017 Oct 19. Cancer Cell. 2017. PMID: 29056426 Free PMC article.

2

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Manning BD, et al. Mol Cell. 2002 Jul;10(1):151-62. doi: 10.1016/s1097-2765(02)00568-3. Mol Cell. 2002. PMID: 12150915 Free article.

3

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tee AR, et al. Among authors: manning bd. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. doi: 10.1073/pnas.202476899. Epub 2002 Sep 23. Proc Natl Acad Sci U S A. 2002. PMID: 12271141 Free PMC article.

4

The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. Shaw RJ, et al. Among authors: manning bd. Cancer Cell. 2004 Jul;6(1):91-9. doi: 10.1016/j.ccr.2004.06.007. Cancer Cell. 2004. PMID: 15261145 Free article.

5

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.

Manning BD. Manning BD. J Cell Biol. 2004 Nov 8;167(3):399-403. doi: 10.1083/jcb.200408161. J Cell Biol. 2004. PMID: 15533996 Free PMC article. Review.

6

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC. Manning BD, et al. Genes Dev. 2005 Aug 1;19(15):1773-8. doi: 10.1101/gad.1314605. Epub 2005 Jul 18. Genes Dev. 2005. PMID: 16027169 Free PMC article.

7

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.

Kwiatkowski DJ, Manning BD. Kwiatkowski DJ, et al. Among authors: manning bd. Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R251-8. doi: 10.1093/hmg/ddi260. Hum Mol Genet. 2005. PMID: 16244323 Review.

8

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Ozcan U, et al. Among authors: manning bd. Mol Cell. 2008 Mar 14;29(5):541-51. doi: 10.1016/j.molcel.2007.12.023. Mol Cell. 2008. PMID: 18342602 Free PMC article.

9

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD. Huang J, et al. Among authors: manning bd. Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14. Mol Cell Biol. 2008. PMID: 18411301 Free PMC article.

10

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

Huang J, Manning BD. Huang J, et al. Among authors: manning bd. Biochem J. 2008 Jun 1;412(2):179-90. doi: 10.1042/BJ20080281. Biochem J. 2008. PMID: 18466115 Free PMC article. Review.

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