Mizutani H - Search Results

1

Pirarubicin, an Anthracycline Anticancer Agent, Induces Apoptosis Through Generation of Hydrogen Peroxide.

Mizutani H, Hotta S, Nishimoto A, Ikemura K, Miyazawa D, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S. Mizutani H, et al. Anticancer Res. 2017 Nov;37(11):6063-6069. doi: 10.21873/anticanres.12054. Anticancer Res. 2017. PMID: 29061786

2

Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide.

Mizutani H, Tada-Oikawa S, Hiraku Y, Oikawa S, Kojima M, Kawanishi S. Mizutani H, et al. J Biol Chem. 2002 Aug 23;277(34):30684-9. doi: 10.1074/jbc.M204353200. Epub 2002 Jun 14. J Biol Chem. 2002. PMID: 12068015 Free article.

3

Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide.

Mizutani H, Tada-Oikawa S, Hiraku Y, Kojima M, Kawanishi S. Mizutani H, et al. Life Sci. 2005 Feb 11;76(13):1439-53. doi: 10.1016/j.lfs.2004.05.040. Epub 2005 Jan 20. Life Sci. 2005. PMID: 15680309

Our previous study has demonstrated that TAS-103, a topoisomerase inhibitor, induces apoptosis through DNA cleavage and subsequent H(2)O(2) generation mediated by NAD(P)H oxidase activation [H. Mizutani et al. J. Biol. ...This oxidative DNA damage caus …

Our previous study has demonstrated that TAS-103, a topoisomerase inhibitor, induces apoptosis through DNA cleavage and subsequent H( …

4

Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide.

Mizutani H, Hiraku Y, Tada-Oikawa S, Murata M, Ikemura K, Iwamoto T, Kagawa Y, Okuda M, Kawanishi S. Mizutani H, et al. Cancer Sci. 2010 Oct;101(10):2214-9. doi: 10.1111/j.1349-7006.2010.01645.x. Epub 2010 Jul 7. Cancer Sci. 2010. PMID: 20624163 Free PMC article.

5

Oxidative DNA Damage Induced by Pirarubicin, an Anthracycline Anticancer Agent, in the Presence of Copper(II).

Mizutani H, Nishimoto A, Hotta S, Ikemura K, Imai M, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S. Mizutani H, et al. Anticancer Res. 2018 May;38(5):2643-2648. doi: 10.21873/anticanres.12506. Anticancer Res. 2018. PMID: 29715084

6

Oxidative DNA Damage and Apoptosis Induced by Aclarubicin, an Anthracycline: Role of Hydrogen Peroxide and Copper.

Mizutani H, Hayashi Y, Hashimoto M, Imai M, Ichimaru Y, Kitamura Y, Ikemura K, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S. Mizutani H, et al. Anticancer Res. 2019 Jul;39(7):3443-3451. doi: 10.21873/anticanres.13490. Anticancer Res. 2019. PMID: 31262868

7

Idarubicin, an Anthracycline, Induces Oxidative DNA Damage in the Presence of Copper (II).

Mizutani H, Shiga C, Imai M, Ikemura K, Kitamura Y, Ohta K, Miyazawa D, Sakanashi M, Tahira T, Maeda T, Hiraku Y, Kawanishi S. Mizutani H, et al. Anticancer Res. 2020 Oct;40(10):5399-5404. doi: 10.21873/anticanres.14548. Anticancer Res. 2020. PMID: 32988859

8

Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase.

Mizutani H, Oikawa S, Hiraku Y, Murata M, Kojima M, Kawanishi S. Mizutani H, et al. Cancer Sci. 2003 Aug;94(8):686-91. doi: 10.1111/j.1349-7006.2003.tb01503.x. Cancer Sci. 2003. PMID: 12901793 Free PMC article.

9

DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect.

Iwamoto T, Hiraku Y, Oikawa S, Mizutani H, Kojima M, Kawanishi S. Iwamoto T, et al. Among authors: mizutani h. Cancer Sci. 2004 May;95(5):454-8. doi: 10.1111/j.1349-7006.2004.tb03231.x. Cancer Sci. 2004. PMID: 15132775 Free PMC article.

10

The enhancement of oxidative DNA damage by anti-diabetic metformin, buformin, and phenformin, via nitrogen-centered radicals.

Ohnishi S, Mizutani H, Kawanishi S. Ohnishi S, et al. Among authors: mizutani h. Free Radic Res. 2016 Aug;50(8):929-37. doi: 10.1080/10715762.2016.1204651. Free Radic Res. 2016. PMID: 27328723

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