Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function.
Nagasu H, Sogawa Y, Kidokoro K, Itano S, Yamamoto T, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Wigley WC, Proksch JW, Meyer CJ, Kashihara N.
Nagasu H, et al. Among authors: itano s.
FASEB J. 2019 Nov;33(11):12253-12263. doi: 10.1096/fj.201900217R. Epub 2019 Aug 30.
FASEB J. 2019.
PMID: 31431054
Free PMC article.
Our data show that dh404 significantly reduced proteinuria-induced tubular cell mitochondrial damage, suggesting that improved redox balance and mitochondrial function and suppression of inflammation underlie the cytoprotective mechanism of Nrf2 activators, including bardoxolone …
Our data show that dh404 significantly reduced proteinuria-induced tubular cell mitochondrial damage, suggesting that improved redox balance …