Meng Q - Search Results

1

The development of an effective synthetic route of lesinurad (RDEA594).

Meng Q, Zhao T, Kang D, Huang B, Zhan P, Liu X. Meng Q, et al. Chem Cent J. 2017 Sep 5;11(1):86. doi: 10.1186/s13065-017-0316-y. Chem Cent J. 2017. PMID: 29086884 Free PMC article.

2

Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.

Meng Q, Chen X, Kang D, Huang B, Li W, Zhan P, Daelemans D, De Clercq E, Pannecouque C, Liu X. Meng Q, et al. Eur J Med Chem. 2016 Jun 10;115:53-62. doi: 10.1016/j.ejmech.2016.02.068. Epub 2016 Mar 3. Eur J Med Chem. 2016. PMID: 26994843

3

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

Kang D, Fang Z, Huang B, Lu X, Zhang H, Xu H, Huo Z, Zhou Z, Yu Z, Meng Q, Wu G, Ding X, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: meng q. J Med Chem. 2017 May 25;60(10):4424-4443. doi: 10.1021/acs.jmedchem.7b00332. Epub 2017 May 15. J Med Chem. 2017. PMID: 28481112

4

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.

Zhao T, Meng Q, Kang D, Ji J, De Clercq E, Pannecouque C, Liu X, Zhan P. Zhao T, et al. Among authors: meng q. Eur J Med Chem. 2019 Nov 15;182:111619. doi: 10.1016/j.ejmech.2019.111619. Epub 2019 Aug 14. Eur J Med Chem. 2019. PMID: 31434039

5

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.

Zhao T, Meng Q, Sun Z, Chen Y, Ai W, Zhao Z, Kang D, Dong Y, Liang R, Wu T, Pang J, Liu X, Zhan P. Zhao T, et al. Among authors: meng q. J Med Chem. 2020 Oct 8;63(19):10829-10854. doi: 10.1021/acs.jmedchem.0c00223. Epub 2020 Sep 21. J Med Chem. 2020. PMID: 32897699

6

Novel fluorine-containing DAPY derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2014072419.

Meng Q, Liu N, Huang B, Zhan P, Liu X. Meng Q, et al. Expert Opin Ther Pat. 2015;25(12):1477-86. doi: 10.1517/13543776.2016.1088832. Epub 2015 Sep 28. Expert Opin Ther Pat. 2015. PMID: 26415039

7

Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket.

Chen X, Meng Q, Qiu L, Zhan P, Liu H, De Clercq E, Pannecouque C, Liu X. Chen X, et al. Among authors: meng q. Chem Biol Drug Des. 2015 Jul;86(1):122-8. doi: 10.1111/cbdd.12471. Epub 2014 Dec 5. Chem Biol Drug Des. 2015. PMID: 25358434

8

Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

Chen X, Liu X, Meng Q, Wang D, Liu H, De Clercq E, Pannecouque C, Balzarini J, Liu X. Chen X, et al. Among authors: meng q. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6593-7. doi: 10.1016/j.bmcl.2013.10.059. Epub 2013 Nov 1. Bioorg Med Chem Lett. 2013. PMID: 24239481

9

Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury.

Cui Y, Zhang M, Xu H, Zhang T, Zhang S, Zhao X, Jiang P, Li J, Ye B, Sun Y, Wang M, Deng Y, Meng Q, Liu Y, Fu Q, Lin J, Wang L, Chen Y. Cui Y, et al. Among authors: meng q. J Med Chem. 2022 Feb 24;65(4):2971-2987. doi: 10.1021/acs.jmedchem.1c01583. Epub 2022 Jan 10. J Med Chem. 2022. PMID: 35005973

10

Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers.

Ye B, Gong J, Li Q, Bao S, Zhang X, Chen J, Meng Q, Chen B, Jiang P, Wang L, Chen Y. Ye B, et al. Among authors: meng q. Mar Drugs. 2020 Mar 23;18(3):176. doi: 10.3390/md18030176. Mar Drugs. 2020. PMID: 32210159 Free PMC article.

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