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Page 1
Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.
Rostami J, Holmqvist S, Lindström V, Sigvardson J, Westermark GT, Ingelsson M, Bergström J, Roybon L, Erlandsson A. Rostami J, et al. Among authors: ingelsson m. J Neurosci. 2017 Dec 6;37(49):11835-11853. doi: 10.1523/JNEUROSCI.0983-17.2017. Epub 2017 Oct 31. J Neurosci. 2017. PMID: 29089438 Free PMC article.
The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties.
Näsström T, Fagerqvist T, Barbu M, Karlsson M, Nikolajeff F, Kasrayan A, Ekberg M, Lannfelt L, Ingelsson M, Bergström J. Näsström T, et al. Among authors: ingelsson m. Free Radic Biol Med. 2011 Feb 1;50(3):428-37. doi: 10.1016/j.freeradbiomed.2010.11.027. Epub 2010 Dec 1. Free Radic Biol Med. 2011. PMID: 21130160
Antibodies against alpha-synuclein reduce oligomerization in living cells.
Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M. Näsström T, et al. Among authors: ingelsson m. PLoS One. 2011;6(10):e27230. doi: 10.1371/journal.pone.0027230. Epub 2011 Oct 31. PLoS One. 2011. PMID: 22073131 Free PMC article.
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.
Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF. Diógenes MJ, et al. Among authors: ingelsson m. J Neurosci. 2012 Aug 22;32(34):11750-62. doi: 10.1523/JNEUROSCI.0234-12.2012. J Neurosci. 2012. PMID: 22915117 Free PMC article.
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation.
Fagerqvist T, Lindström V, Nordström E, Lord A, Tucker SM, Su X, Sahlin C, Kasrayan A, Andersson J, Welander H, Näsström T, Holmquist M, Schell H, Kahle PJ, Kalimo H, Möller C, Gellerfors P, Lannfelt L, Bergström J, Ingelsson M. Fagerqvist T, et al. Among authors: ingelsson m. J Neurochem. 2013 Jul;126(1):131-44. doi: 10.1111/jnc.12175. Epub 2013 Feb 27. J Neurochem. 2013. PMID: 23363402 Free article.
Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.
Fagerqvist T, Näsström T, Ihse E, Lindström V, Sahlin C, Tucker SM, Kasaryan A, Karlsson M, Nikolajeff F, Schell H, Outeiro TF, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J. Fagerqvist T, et al. Among authors: ingelsson m. Amyloid. 2013 Dec;20(4):233-44. doi: 10.3109/13506129.2013.835726. Epub 2013 Sep 20. Amyloid. 2013. PMID: 24053224
Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice.
Lindström V, Fagerqvist T, Nordström E, Eriksson F, Lord A, Tucker S, Andersson J, Johannesson M, Schell H, Kahle PJ, Möller C, Gellerfors P, Bergström J, Lannfelt L, Ingelsson M. Lindström V, et al. Among authors: ingelsson m. Neurobiol Dis. 2014 Sep;69:134-43. doi: 10.1016/j.nbd.2014.05.009. Epub 2014 May 20. Neurobiol Dis. 2014. PMID: 24851801
219 results