Zhou J - Search Results

1

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).

Liu Z, Zhu Y, Chen H, Wang P, Mei FC, Ye N, Cheng X, Zhou J. Liu Z, et al. Among authors: zhou j. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5163-5166. doi: 10.1016/j.bmcl.2017.10.056. Epub 2017 Oct 25. Bioorg Med Chem Lett. 2017. PMID: 29100797 Free PMC article.

2

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.

Chen H, Tsalkova T, Mei FC, Hu Y, Cheng X, Zhou J. Chen H, et al. Among authors: zhou j. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43. doi: 10.1016/j.bmcl.2012.04.082. Epub 2012 Apr 26. Bioorg Med Chem Lett. 2012. PMID: 22607683 Free PMC article.

3

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.

Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X. Almahariq M, et al. Among authors: zhou j. Mol Pharmacol. 2013 Jan;83(1):122-8. doi: 10.1124/mol.112.080689. Epub 2012 Oct 11. Mol Pharmacol. 2013. PMID: 23066090 Free PMC article.

4

Identification and characterization of small molecules as potent and specific EPAC2 antagonists.

Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J. Chen H, et al. Among authors: zhou j. J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15. J Med Chem. 2013. PMID: 23286832 Free PMC article.

5

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: zhou j. Eur J Med Chem. 2013 Apr;62:498-507. doi: 10.1016/j.ejmech.2013.01.023. Epub 2013 Jan 26. Eur J Med Chem. 2013. PMID: 23416191 Free PMC article.

6

Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.

Chen H, Ding C, Wild C, Liu H, Wang T, White MA, Cheng X, Zhou J. Chen H, et al. Among authors: zhou j. Tetrahedron Lett. 2013 Mar 20;54(12):1546-1549. doi: 10.1016/j.tetlet.2013.01.024. Tetrahedron Lett. 2013. PMID: 23459418 Free PMC article.

7

Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.

Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Chen H, et al. Among authors: zhou j. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185. doi: 10.1021/ml3003082. Epub 2013 Jan 15. ACS Med Chem Lett. 2013. PMID: 23459613 Free PMC article.

8

Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q, Zhou J. Ding C, et al. Among authors: zhou j. J Med Chem. 2013 Nov 14;56(21):8814-25. doi: 10.1021/jm401248x. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24128046 Free PMC article.

9

Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).

Chen H, Wild C, Zhou X, Ye N, Cheng X, Zhou J. Chen H, et al. Among authors: zhou x, zhou j. J Med Chem. 2014 May 8;57(9):3651-65. doi: 10.1021/jm401425e. Epub 2013 Nov 27. J Med Chem. 2014. PMID: 24256330 Free PMC article. Review.

10

Small molecule inhibitors targeting activator protein 1 (AP-1).

Ye N, Ding Y, Wild C, Shen Q, Zhou J. Ye N, et al. Among authors: zhou j. J Med Chem. 2014 Aug 28;57(16):6930-48. doi: 10.1021/jm5004733. Epub 2014 May 27. J Med Chem. 2014. PMID: 24831826 Free PMC article.

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