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ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.
Tripathi P, Shine EE, Healy AR, Kim CS, Herzon SB, Bruner SD, Crawford JM. Tripathi P, et al. Among authors: crawford jm. J Am Chem Soc. 2017 Dec 13;139(49):17719-17722. doi: 10.1021/jacs.7b09971. Epub 2017 Nov 28. J Am Chem Soc. 2017. PMID: 29112397 Free PMC article.
The colibactin warhead crosslinks DNA.
Vizcaino MI, Crawford JM. Vizcaino MI, et al. Among authors: crawford jm. Nat Chem. 2015 May;7(5):411-7. doi: 10.1038/nchem.2221. Epub 2015 Apr 6. Nat Chem. 2015. PMID: 25901819 Free PMC article.
A Mechanistic Model for Colibactin-Induced Genotoxicity.
Healy AR, Nikolayevskiy H, Patel JR, Crawford JM, Herzon SB. Healy AR, et al. Among authors: crawford jm. J Am Chem Soc. 2016 Dec 7;138(48):15563-15570. doi: 10.1021/jacs.6b10354. Epub 2016 Nov 28. J Am Chem Soc. 2016. PMID: 27934011 Free PMC article.
Structure elucidation of colibactin and its DNA cross-links.
Xue M, Kim CS, Healy AR, Wernke KM, Wang Z, Frischling MC, Shine EE, Wang W, Herzon SB, Crawford JM. Xue M, et al. Among authors: crawford jm. Science. 2019 Sep 6;365(6457):eaax2685. doi: 10.1126/science.aax2685. Epub 2019 Aug 8. Science. 2019. PMID: 31395743 Free PMC article.
505 results