Griffin S - Search Results

1

Highly Selective Dopamine D₃ Receptor Antagonists with Arylated Diazaspiro Alkane Cores.

Reilly SW, Griffin S, Taylor M, Sahlholm K, Weng CC, Xu K, Jacome DA, Luedtke RR, Mach RH. Reilly SW, et al. Among authors: griffin s. J Med Chem. 2017 Dec 14;60(23):9905-9910. doi: 10.1021/acs.jmedchem.7b01248. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29125762 Free PMC article.

2

Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D₃ Receptor (D₃R) Ligand Promiscuity across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs).

Reilly SW, Riad AA, Hsieh CJ, Sahlholm K, Jacome DA, Griffin S, Taylor M, Weng CC, Xu K, Kirschner N, Luedtke RR, Parry C, Malhotra S, Karanicolas J, Mach RH. Reilly SW, et al. Among authors: griffin s. J Med Chem. 2019 May 23;62(10):5132-5147. doi: 10.1021/acs.jmedchem.9b00412. Epub 2019 May 6. J Med Chem. 2019. PMID: 31021617

3

Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.

Kumar R, Riddle LR, Griffin SA, Chu W, Vangveravong S, Neisewander J, Mach RH, Luedtke RR. Kumar R, et al. Among authors: griffin sa. Neuropharmacology. 2009 May-Jun;56(6-7):956-69. doi: 10.1016/j.neuropharm.2009.01.019. Epub 2009 Feb 5. Neuropharmacology. 2009. PMID: 19371586 Free PMC article.

4

Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways.

Taylor M, Grundt P, Griffin SA, Newman AH, Luedtke RR. Taylor M, et al. Synapse. 2010 Mar;64(3):251-66. doi: 10.1002/syn.20725. Synapse. 2010. PMID: 19924694 Free PMC article.

5

N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.

Banala AK, Levy BA, Khatri SS, Furman CA, Roof RA, Mishra Y, Griffin SA, Sibley DR, Luedtke RR, Newman AH. Banala AK, et al. Among authors: griffin sa. J Med Chem. 2011 May 26;54(10):3581-94. doi: 10.1021/jm200288r. Epub 2011 May 2. J Med Chem. 2011. PMID: 21495689 Free PMC article.

6

Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds.

Luedtke RR, Mishra Y, Wang Q, Griffin SA, Bell-Horner C, Taylor M, Vangveravong S, Dillon GH, Huang RQ, Reichert DE, Mach RH. Luedtke RR, et al. Among authors: griffin sa. ACS Chem Neurosci. 2012 Dec 19;3(12):1050-62. doi: 10.1021/cn300142q. Epub 2012 Oct 12. ACS Chem Neurosci. 2012. PMID: 23259040 Free PMC article.

7

Analogues of Arylamide Phenylpiperazine Ligands To Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity.

Hayatshahi HS, Xu K, Griffin SA, Taylor M, Mach RH, Liu J, Luedtke RR. Hayatshahi HS, et al. Among authors: griffin sa. ACS Chem Neurosci. 2018 Dec 19;9(12):2972-2983. doi: 10.1021/acschemneuro.8b00142. Epub 2018 Jul 30. ACS Chem Neurosci. 2018. PMID: 30010318

8

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D₃ receptor ligands.

Chen PJ, Taylor M, Griffin SA, Amani A, Hayatshahi H, Korzekwa K, Ye M, Mach RH, Liu J, Luedtke RR, Gordon JC, Blass BE. Chen PJ, et al. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2690-2694. doi: 10.1016/j.bmcl.2019.07.020. Epub 2019 Jul 11. Bioorg Med Chem Lett. 2019. PMID: 31387791

9

Evaluation of Substituted N-Phenylpiperazine Analogs as D3 vs. D2 Dopamine Receptor Subtype Selective Ligands.

Lee B, Taylor M, Griffin SA, McInnis T, Sumien N, Mach RH, Luedtke RR. Lee B, et al. Molecules. 2021 May 26;26(11):3182. doi: 10.3390/molecules26113182. Molecules. 2021. PMID: 34073405 Free PMC article.

10

Evaluation of the D3 dopamine receptor selective antagonist PG01037 on L-dopa-dependent abnormal involuntary movements in rats.

Kumar R, Riddle L, Griffin SA, Grundt P, Newman AH, Luedtke RR. Kumar R, et al. Neuropharmacology. 2009 May-Jun;56(6-7):944-55. doi: 10.1016/j.neuropharm.2009.01.020. Epub 2009 Feb 5. Neuropharmacology. 2009. PMID: 19371585 Free PMC article.

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