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Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk.
Shashar M, Belghasem ME, Matsuura S, Walker J, Richards S, Alousi F, Rijal K, Kolachalama VB, Balcells M, Odagi M, Nagasawa K, Henderson JM, Gautam A, Rushmore R, Francis J, Kirchhofer D, Kolandaivelu K, Sherr DH, Edelman ER, Ravid K, Chitalia VC. Shashar M, et al. Among authors: sherr dh. Sci Transl Med. 2017 Nov 22;9(417):eaam8475. doi: 10.1126/scitranslmed.aam8475. Sci Transl Med. 2017. PMID: 29167396 Free PMC article.
The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia.
Shivanna S, Kolandaivelu K, Shashar M, Belghasim M, Al-Rabadi L, Balcells M, Zhang A, Weinberg J, Francis J, Pollastri MP, Edelman ER, Sherr DH, Chitalia VC. Shivanna S, et al. Among authors: sherr dh. J Am Soc Nephrol. 2016 Jan;27(1):189-201. doi: 10.1681/ASN.2014121241. Epub 2015 May 27. J Am Soc Nephrol. 2016. PMID: 26019318 Free PMC article.
Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.
Arinze NV, Yin W, Lotfollahzadeh S, Napoleon MA, Richards S, Walker JA, Belghasem M, Ravid JD, Hassan Kamel M, Whelan SA, Lee N, Siracuse JJ, Anderson S, Farber A, Sherr D, Francis J, Hamburg NM, Rahimi N, Chitalia VC. Arinze NV, et al. J Clin Invest. 2022 Jan 4;132(1):e142260. doi: 10.1172/JCI142260. J Clin Invest. 2022. PMID: 34752422 Free PMC article.
In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.
Parks AJ, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. Parks AJ, et al. Among authors: sherr dh. Mol Pharmacol. 2014 Nov;86(5):593-608. doi: 10.1124/mol.114.093369. Epub 2014 Aug 26. Mol Pharmacol. 2014. PMID: 25159092 Free PMC article.
141 results