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MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.
Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC. Farrell AS, et al. Among authors: murphy dj. Nat Commun. 2017 Nov 23;8(1):1728. doi: 10.1038/s41467-017-01967-6. Nat Commun. 2017. PMID: 29170413 Free PMC article.
Modelling Myc inhibition as a cancer therapy.
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI. Soucek L, et al. Among authors: murphy dj. Nature. 2008 Oct 2;455(7213):679-83. doi: 10.1038/nature07260. Epub 2008 Aug 17. Nature. 2008. PMID: 18716624 Free PMC article.
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ. Liu L, et al. Among authors: murphy dj. Nature. 2012 Mar 28;483(7391):608-12. doi: 10.1038/nature10927. Nature. 2012. PMID: 22460906
Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.
Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG. Ichim G, et al. Among authors: murphy dj. Mol Cell. 2015 Mar 5;57(5):860-872. doi: 10.1016/j.molcel.2015.01.018. Epub 2015 Feb 19. Mol Cell. 2015. PMID: 25702873 Free PMC article.
BIM's up first.
Murphy DJ, Muthalagu N. Murphy DJ, et al. Mol Cell Oncol. 2014 Dec 1;2(2):e975083. doi: 10.4161/23723556.2014.975083. eCollection 2015 Apr-Jun. Mol Cell Oncol. 2014. PMID: 27308426 Free PMC article.
Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A. Sarosiek KA, et al. Among authors: murphy dj. Cancer Cell. 2017 Jan 9;31(1):142-156. doi: 10.1016/j.ccell.2016.11.011. Epub 2016 Dec 22. Cancer Cell. 2017. PMID: 28017613 Free PMC article.
Calcium signalling links MYC to NUAK1.
Monteverde T, Tait-Mulder J, Hedley A, Knight JR, Sansom OJ, Murphy DJ. Monteverde T, et al. Among authors: murphy dj. Oncogene. 2018 Feb 22;37(8):982-992. doi: 10.1038/onc.2017.394. Epub 2017 Nov 6. Oncogene. 2018. PMID: 29106388 Free PMC article.
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.
Port J, Muthalagu N, Raja M, Ceteci F, Monteverde T, Kruspig B, Hedley A, Kalna G, Lilla S, Neilson L, Brucoli M, Gyuraszova K, Tait-Mulder J, Mezna M, Svambaryte S, Bryson A, Sumpton D, McVie A, Nixon C, Drysdale M, Esumi H, Murray GI, Sansom OJ, Zanivan SR, Murphy DJ. Port J, et al. Among authors: murphy dj. Cancer Discov. 2018 May;8(5):632-647. doi: 10.1158/2159-8290.CD-17-0533. Epub 2018 Mar 2. Cancer Discov. 2018. PMID: 29500295 Free PMC article.
739 results