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The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis.
Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR. Baquié M, et al. Among authors: wollheim cb. Hum Mol Genet. 2018 Jan 15;27(2):406. doi: 10.1093/hmg/ddx402. Hum Mol Genet. 2018. PMID: 29186426 Free article. No abstract available.
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis.
Baquié M, St-Onge L, Kerr-Conte J, Cobo-Vuilleumier N, Lorenzo PI, Jimenez Moreno CM, Cederroth CR, Nef S, Borot S, Bosco D, Wang H, Marchetti P, Pattou F, Wollheim CB, Gauthier BR. Baquié M, et al. Among authors: wollheim cb. Hum Mol Genet. 2011 Jul 15;20(14):2823-33. doi: 10.1093/hmg/ddr193. Epub 2011 May 2. Hum Mol Genet. 2011. PMID: 21536586
Synaptotagmins bind calcium to release insulin.
Gauthier BR, Wollheim CB. Gauthier BR, et al. Among authors: wollheim cb. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1279-86. doi: 10.1152/ajpendo.90568.2008. Epub 2008 Aug 19. Am J Physiol Endocrinol Metab. 2008. PMID: 18713958 Free article. Review.
Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB. Kirkpatrick CL, et al. Among authors: wollheim cb. J Biol Chem. 2011 Sep 16;286(37):32300-12. doi: 10.1074/jbc.M111.247866. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784843 Free PMC article.
366 results