Yuan H - Search Results

1

Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors.

Yuan H, Liu Q, Zhang L, Hu S, Chen T, Li H, Chen Y, Xu Y, Lu T. Yuan H, et al. Eur J Med Chem. 2018 Jan 1;143:491-502. doi: 10.1016/j.ejmech.2017.11.073. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29202410

2

Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors.

Chen XM, Lu T, Lu S, Li HF, Yuan HL, Ran T, Liu HC, Chen YD. Chen XM, et al. J Mol Model. 2010 Jul;16(7):1195-204. doi: 10.1007/s00894-009-0630-y. Epub 2009 Dec 18. J Mol Model. 2010. PMID: 20020310

3

Novel strategy for three-dimensional fragment-based lead discovery.

Yuan H, Lu T, Ran T, Liu H, Lu S, Tai W, Leng Y, Zhang W, Wang J, Chen Y. Yuan H, et al. J Chem Inf Model. 2011 Apr 25;51(4):959-74. doi: 10.1021/ci200003c. Epub 2011 Mar 25. J Chem Inf Model. 2011. PMID: 21438547

4

A selectivity study on mTOR/PI3Kα inhibitors by homology modeling and 3D-QSAR.

Ran T, Lu T, Yuan H, Liu H, Wang J, Zhang W, Leng Y, Lin G, Zhuang S, Chen Y. Ran T, et al. Among authors: yuan h. J Mol Model. 2012 Jan;18(1):171-86. doi: 10.1007/s00894-011-1034-3. Epub 2011 Apr 27. J Mol Model. 2012. PMID: 21523553

5

Pharmacophore modeling and virtual screening studies to identify new c-Met inhibitors.

Tai W, Lu T, Yuan H, Wang F, Liu H, Lu S, Leng Y, Zhang W, Jiang Y, Chen Y. Tai W, et al. Among authors: yuan h. J Mol Model. 2012 Jul;18(7):3087-100. doi: 10.1007/s00894-011-1328-5. Epub 2011 Dec 28. J Mol Model. 2012. PMID: 22203475

6

Combined pharmacophore modeling, docking, and 3D-QSAR studies of PLK1 inhibitors.

Lu S, Liu HC, Chen YD, Yuan HL, Sun SL, Gao YP, Yang P, Zhang L, Lu T. Lu S, et al. Int J Mol Sci. 2011;12(12):8713-39. doi: 10.3390/ijms12128713. Epub 2011 Dec 1. Int J Mol Sci. 2011. PMID: 22272100 Free PMC article.

7

Identification of novel polo-like kinase 1 inhibitors by a hybrid virtual screening.

Lu S, Sun SL, Liu HC, Chen YD, Yuan HL, Gao YP, Yang P, Lu T. Lu S, et al. Chem Biol Drug Des. 2012 Aug;80(2):328-39. doi: 10.1111/j.1747-0285.2012.01412.x. Epub 2012 Jun 8. Chem Biol Drug Des. 2012. PMID: 22583481

8

Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase.

Xin B, Tang W, Wang Y, Lin G, Liu H, Jiao Y, Zhu Y, Yuan H, Chen Y, Lu T. Xin B, et al. Among authors: yuan h. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4783-6. doi: 10.1016/j.bmcl.2012.05.053. Epub 2012 May 24. Bioorg Med Chem Lett. 2012. PMID: 22704238

9

De novo design of N-(pyridin-4-ylmethyl)aniline derivatives as KDR inhibitors: 3D-QSAR, molecular fragment replacement, protein-ligand interaction fingerprint, and ADMET prediction.

Zhang Y, Liu H, Jiao Y, Yuan H, Wang F, Lu S, Yao S, Ke Z, Tai W, Jiang Y, Chen Y, Lu T. Zhang Y, et al. Among authors: yuan h. Mol Divers. 2012 Nov;16(4):787-802. doi: 10.1007/s11030-012-9405-y. Epub 2012 Oct 23. Mol Divers. 2012. PMID: 23090418

10

Molecular modelling on small molecular CDK2 inhibitors: an integrated approach using a combination of molecular docking, 3D-QSAR and pharmacophore modelling.

Yuan H, Liu H, Tai W, Wang F, Zhang Y, Yao S, Ran T, Lu S, Ke Z, Xiong X, Xu J, Chen Y, Lu T. Yuan H, et al. SAR QSAR Environ Res. 2013 Oct;24(10):795-817. doi: 10.1080/1062936X.2013.815655. Epub 2013 Aug 13. SAR QSAR Environ Res. 2013. PMID: 23941641

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