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The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A. Martinez Hernandez A, et al. Among authors: schneider a. EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825. EMBO Mol Med. 2018. PMID: 29208638 Free PMC article.
Turn plasticity distinguishes different modes of amyloid-β aggregation.
Rezaei-Ghaleh N, Amininasab M, Giller K, Kumar S, Stündl A, Schneider A, Becker S, Walter J, Zweckstetter M. Rezaei-Ghaleh N, et al. Among authors: schneider a. J Am Chem Soc. 2014 Apr 2;136(13):4913-9. doi: 10.1021/ja411707y. Epub 2014 Mar 21. J Am Chem Soc. 2014. PMID: 24617810
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.
Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A. Kunadt M, et al. Among authors: schneider a. Acta Neuropathol. 2015 May;129(5):695-713. doi: 10.1007/s00401-015-1408-1. Epub 2015 Mar 17. Acta Neuropathol. 2015. PMID: 25778619 Free PMC article.
Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.
Lehmer C, Oeckl P, Weishaupt JH, Volk AE, Diehl-Schmid J, Schroeter ML, Lauer M, Kornhuber J, Levin J, Fassbender K, Landwehrmeyer B; German Consortium for Frontotemporal Lobar Degeneration; Schludi MH, Arzberger T, Kremmer E, Flatley A, Feederle R, Steinacker P, Weydt P, Ludolph AC, Edbauer D, Otto M. Lehmer C, et al. EMBO Mol Med. 2017 Jul;9(7):859-868. doi: 10.15252/emmm.201607486. EMBO Mol Med. 2017. PMID: 28408402 Free PMC article.
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa.
Pellkofer H, Ihler F, Weiss BG, Trothe J, Kadavath H, Chongtham M, Kunadt M, Riedel D, Lornsen F, Wilken P, Bartels C, Hirschel S, Russo SG, Stransky E, Trojan L, Schmidt B, Mandelkow E, Zweckstetter M, Canis M, Schneider A. Pellkofer H, et al. Among authors: schneider a. Eur Arch Psychiatry Clin Neurosci. 2019 Dec;269(8):973-984. doi: 10.1007/s00406-018-0955-6. Epub 2018 Nov 12. Eur Arch Psychiatry Clin Neurosci. 2019. PMID: 30421149
The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M. Franzmeier N, et al. Among authors: schneider a. Mol Psychiatry. 2021 Feb;26(2):614-628. doi: 10.1038/s41380-019-0404-6. Epub 2019 Mar 21. Mol Psychiatry. 2021. PMID: 30899092 Free PMC article.
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.
Lepko T, Pusch M, Müller T, Schulte D, Ehses J, Kiebler M, Hasler J, Huttner HB, Vandenbroucke RE, Vandendriessche C, Modic M, Martin-Villalba A, Zhao S, LLorens-Bobadilla E, Schneider A, Fischer A, Breunig CT, Stricker SH, Götz M, Ninkovic J. Lepko T, et al. Among authors: schneider a. EMBO J. 2019 Sep 2;38(17):e100481. doi: 10.15252/embj.2018100481. Epub 2019 Jul 15. EMBO J. 2019. PMID: 31304985 Free PMC article.
A combined miRNA-piRNA signature to detect Alzheimer's disease.
Jain G, Stuendl A, Rao P, Berulava T, Pena Centeno T, Kaurani L, Burkhardt S, Delalle I, Kornhuber J, Hüll M, Maier W, Peters O, Esselmann H, Schulte C, Deuschle C, Synofzik M, Wiltfang J, Mollenhauer B, Maetzler W, Schneider A, Fischer A. Jain G, et al. Among authors: schneider a. Transl Psychiatry. 2019 Oct 7;9(1):250. doi: 10.1038/s41398-019-0579-2. Transl Psychiatry. 2019. PMID: 31591382 Free PMC article.
4,968 results