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Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.
Gao J, Yao L, Xia T, Liao X, Zhu D, Xiang Y. Gao J, et al. Among authors: zhu d. FASEB J. 2018 Apr;32(4):2036-2045. doi: 10.1096/fj.201700397RR. Epub 2018 Jan 5. FASEB J. 2018. PMID: 29208702
The unique binding sites distinguish Ro 61-8048 as a noncompetitive and highly selective inhibitor from other competitive inhibitors, which should facilitate further optimization of Ro 61-8048 and the development of new inhibitory drugs to hKMO.-Gao, J., Yao, L., Xia, T., Liao, X …
The unique binding sites distinguish Ro 61-8048 as a noncompetitive and highly selective inhibitor from other competitive inhibitors, which …
Optimizing protein crystal growth through dynamic seeding.
Zhu DY, Zhu YQ, Xiang Y, Wang DC. Zhu DY, et al. Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):772-5. doi: 10.1107/S0907444904028768. Epub 2005 May 26. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 15930637
Structural insights into FSP1 catalysis and ferroptosis inhibition.
Lv Y, Liang C, Sun Q, Zhu J, Xu H, Li X, Li YY, Wang Q, Yuan H, Chu B, Zhu D. Lv Y, et al. Among authors: zhu d, zhu j. Nat Commun. 2023 Sep 22;14(1):5933. doi: 10.1038/s41467-023-41626-7. Nat Commun. 2023. PMID: 37739943 Free PMC article.
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