Zhou Q - Search Results

1

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.

Chiang MJ, Musayev FN, Kosikova M, Lin Z, Gao Y, Mosier PD, Althufairi B, Ye Z, Zhou Q, Desai UR, Xie H, Safo MK. Chiang MJ, et al. Among authors: zhou q. Emerg Microbes Infect. 2017 Dec 6;6(12):e108. doi: 10.1038/emi.2017.96. Emerg Microbes Infect. 2017. PMID: 29209052 Free PMC article.

2

Crystal structures of influenza A virus matrix protein M1: variations on a theme.

Safo MK, Musayev FN, Mosier PD, Zhou Q, Xie H, Desai UR. Safo MK, et al. Among authors: zhou q. PLoS One. 2014 Oct 8;9(10):e109510. doi: 10.1371/journal.pone.0109510. eCollection 2014. PLoS One. 2014. PMID: 25295515 Free PMC article.

3

Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.

Mosier PD, Chiang MJ, Lin Z, Gao Y, Althufairi B, Zhou Q, Musayev F, Safo MK, Xie H, Desai UR. Mosier PD, et al. Among authors: zhou q. Sci Rep. 2016 Aug 30;6:32340. doi: 10.1038/srep32340. Sci Rep. 2016. PMID: 27573445 Free PMC article.

4

A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds.

Sidhu PS, Zhou Q, Desai UR. Sidhu PS, et al. Among authors: zhou q. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5716-5720. doi: 10.1016/j.bmcl.2014.10.059. Epub 2014 Oct 23. Bioorg Med Chem Lett. 2014. PMID: 25453807

5

Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.

Abdel Aziz MH, Sidhu PS, Liang A, Kim JY, Mosier PD, Zhou Q, Farrell DH, Desai UR. Abdel Aziz MH, et al. Among authors: zhou q. J Med Chem. 2012 Aug 9;55(15):6888-97. doi: 10.1021/jm300670q. Epub 2012 Jul 25. J Med Chem. 2012. PMID: 22788964 Free PMC article.

6

On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.

Sidhu PS, Mosier PD, Zhou Q, Desai UR. Sidhu PS, et al. Among authors: zhou q. Bioorg Med Chem Lett. 2013 Jan 1;23(1):355-9. doi: 10.1016/j.bmcl.2012.10.079. Epub 2012 Oct 24. Bioorg Med Chem Lett. 2013. PMID: 23164711 Free PMC article.

7

6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells.

Wang X, Wang Z, Sidhu PS, Desai UR, Zhou Q. Wang X, et al. Among authors: zhou q. PLoS One. 2015 Mar 19;10(3):e0116409. doi: 10.1371/journal.pone.0116409. eCollection 2015. PLoS One. 2015. PMID: 25790236 Free PMC article.

8

Sulfated, low-molecular-weight lignins are potent inhibitorsof plasmin, in addition to thrombin and factor Xa: Novel opportunity for controlling complex pathologies.

Henry BL, Abdel Aziz M, Zhou Q, Desai UR. Henry BL, et al. Among authors: zhou q. Thromb Haemost. 2010 Mar;103(3):507-15. doi: 10.1160/TH09-07-0454. Epub 2009 Dec 18. Thromb Haemost. 2010. PMID: 20024500 Free PMC article.

9

First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa.

Verghese J, Liang A, Sidhu PP, Hindle M, Zhou Q, Desai UR. Verghese J, et al. Among authors: zhou q. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4126-9. doi: 10.1016/j.bmcl.2009.06.013. Epub 2009 Jun 6. Bioorg Med Chem Lett. 2009. PMID: 19540113 Free PMC article.

10

Rational design of potent, small, synthetic allosteric inhibitors of thrombin.

Sidhu PS, Liang A, Mehta AY, Abdel Aziz MH, Zhou Q, Desai UR. Sidhu PS, et al. Among authors: zhou q. J Med Chem. 2011 Aug 11;54(15):5522-31. doi: 10.1021/jm2005767. Epub 2011 Jul 18. J Med Chem. 2011. PMID: 21714536 Free PMC article.

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