Zhang M - Search Results

1

Structural insights into the potency of SK channel positive modulators.

Nam YW, Orfali R, Liu T, Yu K, Cui M, Wulff H, Zhang M. Nam YW, et al. Among authors: zhang m. Sci Rep. 2017 Dec 7;7(1):17178. doi: 10.1038/s41598-017-16607-8. Sci Rep. 2017. PMID: 29214998 Free PMC article.

2

Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.

Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF. Zhang M, et al. Among authors: zhang jf. Nat Chem Biol. 2014 Sep;10(9):753-9. doi: 10.1038/nchembio.1592. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108821 Free PMC article.

3

Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface.

Cui M, Qin G, Yu K, Bowers MS, Zhang M. Cui M, et al. Among authors: zhang m. Neurosignals. 2014;22(2):65-78. doi: 10.1159/000367896. Epub 2014 Oct 8. Neurosignals. 2014. PMID: 25300231 Free PMC article. Review.

4

Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides.

Zhang M, Meng XY, Zhang JF, Cui M, Logothetis DE. Zhang M, et al. Among authors: zhang jf. Sci Adv. 2015 Jun 3;1(6):e1500008. doi: 10.1126/sciadv.1500008. Sci Adv. 2015. PMID: 26366439 Free PMC article.

5

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).

Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H. Brown BM, et al. Among authors: zhang m. Mol Pharmacol. 2017 Oct;92(4):469-480. doi: 10.1124/mol.117.109421. Epub 2017 Jul 31. Mol Pharmacol. 2017. PMID: 28760780 Free PMC article.

6

A V-to-F substitution in SK2 channels causes Ca²⁺ hypersensitivity and improves locomotion in a C. elegans ALS model.

Nam YW, Baskoylu SN, Gazgalis D, Orfali R, Cui M, Hart AC, Zhang M. Nam YW, et al. Among authors: zhang m. Sci Rep. 2018 Jul 16;8(1):10749. doi: 10.1038/s41598-018-28783-2. Sci Rep. 2018. PMID: 30013223 Free PMC article.

7

Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca²⁺ sensitivity of SK2 channels.

Nam YW, Cui M, Orfali R, Viegas A, Nguyen M, Mohammed EHM, Zoghebi KA, Rahighi S, Parang K, Zhang M. Nam YW, et al. Among authors: zhang m. Acta Physiol (Oxf). 2021 Jan;231(1):e13552. doi: 10.1111/apha.13552. Epub 2020 Sep 10. Acta Physiol (Oxf). 2021. PMID: 32865319 Free PMC article.

8

Differential modulation of SK channel subtypes by phosphorylation.

Nam YW, Kong D, Wang D, Orfali R, Sherpa RT, Totonchy J, Nauli SM, Zhang M. Nam YW, et al. Among authors: zhang m. Cell Calcium. 2021 Mar;94:102346. doi: 10.1016/j.ceca.2020.102346. Epub 2021 Jan 6. Cell Calcium. 2021. PMID: 33422768 Free PMC article.

9

Subtype-selective positive modulation of K_Ca 2 channels depends on the HA/HB helices.

Nam YW, Cui M, El-Sayed NS, Orfali R, Nguyen M, Yang G, Rahman MA, Lee J, Zhang M. Nam YW, et al. Among authors: zhang m. Br J Pharmacol. 2022 Feb;179(3):460-472. doi: 10.1111/bph.15676. Epub 2021 Oct 1. Br J Pharmacol. 2022. PMID: 34458981 Free PMC article.

10

Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of K_Ca2 Channels.

El-Sayed NS, Nam YW, Egorova PA, Nguyen HM, Orfali R, Rahman MA, Yang G, Wulff H, Bezprozvanny I, Parang K, Zhang M. El-Sayed NS, et al. Among authors: zhang m. J Med Chem. 2022 Jan 13;65(1):303-322. doi: 10.1021/acs.jmedchem.1c01473. Epub 2021 Dec 28. J Med Chem. 2022. PMID: 34962403 Free PMC article.

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