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Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells.
Zhang Z, Langenbach M, Sagar S, Fetsch V, Stritzker J, Severa E, Meng K, Winkler F, Rana N, Zoldan K, Godbole I, Solis S, Weber JS, Rafei-Shamsabadi D, Lehr S, Diehl R, Venhoff AC, Voll RE, Buettner N, Neumann-Haefelin C, Boettler T, Hofmann M, Boerries M, Meiss F, Zeiser R, Thimme R, Herati RS, Bengsch B. Zhang Z, et al. Among authors: winkler f. Nat Immunol. 2025 Jan;26(1):92-104. doi: 10.1038/s41590-024-02027-0. Epub 2024 Dec 19. Nat Immunol. 2025. PMID: 39702858
Differentiating Glioma Recurrence and Pseudoprogression by APTw CEST MRI.
Karimian-Jazi K, Enbergs N, Golubtsov E, Schregel K, Ungermann J, Fels-Palesandro H, Schwarz D, Sturm V, Kernbach JM, Batra D, Ippen FM, Pflüger I, von Knebel Doeberitz N, Heiland S, Bunse L, Platten M, Winkler F, Wick W, Paech D, Bendszus M, Breckwoldt MO. Karimian-Jazi K, et al. Among authors: winkler f. Invest Radiol. 2024 Dec 9. doi: 10.1097/RLI.0000000000001145. Online ahead of print. Invest Radiol. 2024. PMID: 39644107
Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse.
Kats I, Simovic-Lorenz M, Schreiber HS, Sant P, Mallm JP, Körber V, Li A, Velmurugan P, Heuer S, Kües L, Devens F, Sill M, Jugold M, Moustafa M, Abdollahi A, Winkler F, Korshunov A, Pfister SM, Stegle O, Ernst A. Kats I, et al. Among authors: winkler f. Nat Commun. 2024 Nov 29;15(1):10370. doi: 10.1038/s41467-024-54709-w. Nat Commun. 2024. PMID: 39609432 Free PMC article.
337 results