Dai Y - Search Results

1

Design, synthesis, and biological evaluation of deuterated phenylpropionic acid derivatives as potent and long-acting free fatty acid receptor 1 agonists.

Li Z, Liu C, Xu X, Shi W, Li H, Dai Y, Cai X, Huang W, Qian H. Li Z, et al. Among authors: dai y. Bioorg Chem. 2018 Feb;76:303-313. doi: 10.1016/j.bioorg.2017.12.012. Epub 2017 Dec 5. Bioorg Chem. 2018. PMID: 29223807

2

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Wang X, Zhao T, Yang B, Li Z, Cui J, Dai Y, Qiu Q, Qiang H, Huang W, Qian H. Wang X, et al. Among authors: dai y. Bioorg Med Chem. 2015 Jan 1;23(1):132-40. doi: 10.1016/j.bmc.2014.11.016. Epub 2014 Nov 20. Bioorg Med Chem. 2015. PMID: 25481394

3

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Li Z, Pan M, Su X, Dai Y, Fu M, Cai X, Shi W, Huang W, Qian H. Li Z, et al. Among authors: dai y. Bioorg Med Chem. 2016 May 1;24(9):1981-7. doi: 10.1016/j.bmc.2016.03.014. Epub 2016 Mar 7. Bioorg Med Chem. 2016. PMID: 27020683

4

Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.

Qiang H, Gu W, Huang D, Shi W, Qiu Q, Dai Y, Huang W, Qian H. Qiang H, et al. Among authors: dai y. Bioorg Med Chem. 2016 Aug 15;24(16):3353-8. doi: 10.1016/j.bmc.2016.03.061. Epub 2016 Apr 1. Bioorg Med Chem. 2016. PMID: 27068889

5

Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.

Wu Y, Pan M, Dai Y, Liu B, Cui J, Shi W, Qiu Q, Huang W, Qian H. Wu Y, et al. Among authors: dai y. Bioorg Med Chem. 2016 May 15;24(10):2287-97. doi: 10.1016/j.bmc.2016.03.065. Epub 2016 Apr 1. Bioorg Med Chem. 2016. PMID: 27073052

6

Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors.

Gu W, Dai Y, Qiang H, Shi W, Liao C, Zhao F, Huang W, Qian H. Gu W, et al. Among authors: dai y. Bioorg Chem. 2017 Jun;72:116-122. doi: 10.1016/j.bioorg.2017.04.001. Epub 2017 Apr 8. Bioorg Chem. 2017. PMID: 28411406

7

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Li Z, Liu C, Xu X, Qiu Q, Su X, Dai Y, Yang J, Li H, Shi W, Liao C, Pan M, Huang W, Qian H. Li Z, et al. Among authors: dai y. Eur J Med Chem. 2017 Sep 29;138:458-479. doi: 10.1016/j.ejmech.2017.07.001. Epub 2017 Jul 3. Eur J Med Chem. 2017. PMID: 28689096

8

A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects.

Zhou J, Cai X, Huang X, Dai Y, Sun L, Zhang B, Yang B, Lin H, Huang W, Qian H. Zhou J, et al. Among authors: dai y. Eur J Med Chem. 2017 Sep 29;138:1158-1169. doi: 10.1016/j.ejmech.2017.07.046. Epub 2017 Jul 24. Eur J Med Chem. 2017. PMID: 28772236

9

Identification of highly potent and orally available free fatty acid receptor 1 agonists bearing isoxazole scaffold.

Li Z, Liu C, Shi W, Cai X, Dai Y, Liao C, Huang W, Qian H. Li Z, et al. Among authors: dai y. Bioorg Med Chem. 2018 Feb 1;26(3):703-711. doi: 10.1016/j.bmc.2017.12.030. Epub 2017 Dec 24. Bioorg Med Chem. 2018. PMID: 29291938

10

Novel fatty acid chain modified GLP-1 derivatives with prolonged in vivo glucose-lowering ability and balanced glucoregulatory activity.

Cai X, Sun L, Dai Y, Avraham Y, Liu C, Han J, Liu Y, Feng D, Huang W, Qian H. Cai X, et al. Among authors: dai y. Bioorg Med Chem. 2018 May 15;26(9):2599-2609. doi: 10.1016/j.bmc.2018.04.022. Epub 2018 Apr 11. Bioorg Med Chem. 2018. PMID: 29673717

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