Muqit MMK - Search Results

1

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, Stojanovski L, Read KD, Burness K, Blow JJ, Mehellou Y, Muqit MMK. Barini E, et al. Among authors: muqit mmk. Chembiochem. 2018 Mar 2;19(5):425-429. doi: 10.1002/cbic.201700500. Epub 2018 Jan 24. Chembiochem. 2018. PMID: 29226533 Free PMC article.

2

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Woodroof HI, et al. Open Biol. 2011 Nov;1(3):110012. doi: 10.1098/rsob.110012. Open Biol. 2011. PMID: 22645651 Free PMC article.

3

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Kondapalli C, et al. Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080. Open Biol. 2012. PMID: 22724072 Free PMC article.

4

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM. Kazlauskaite A, et al. Biochem J. 2014 May 15;460(1):127-39. doi: 10.1042/BJ20140334. Biochem J. 2014. PMID: 24660806 Free PMC article.

5

PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.

Kazlauskaite A, Muqit MM. Kazlauskaite A, et al. FEBS J. 2015 Jan;282(2):215-23. doi: 10.1111/febs.13127. Epub 2014 Nov 20. FEBS J. 2015. PMID: 25345844 Free PMC article. Review.

6

A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation.

Han C, Pao KC, Kazlauskaite A, Muqit MM, Virdee S. Han C, et al. Chembiochem. 2015 Jul 27;16(11):1574-9. doi: 10.1002/cbic.201500185. Epub 2015 Jun 18. Chembiochem. 2015. PMID: 26010437 Free PMC article.

7

Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization.

Osgerby L, Lai YC, Thornton PJ, Amalfitano J, Le Duff CS, Jabeen I, Kadri H, Miccoli A, Tucker JHR, Muqit MMK, Mehellou Y. Osgerby L, et al. Among authors: muqit mmk. J Med Chem. 2017 Apr 27;60(8):3518-3524. doi: 10.1021/acs.jmedchem.6b01897. Epub 2017 Mar 28. J Med Chem. 2017. PMID: 28323427 Free PMC article.

8

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.

Kumar A, Tamjar J, Waddell AD, Woodroof HI, Raimi OG, Shaw AM, Peggie M, Muqit MM, van Aalten DM. Kumar A, et al. Elife. 2017 Oct 5;6:e29985. doi: 10.7554/eLife.29985. Elife. 2017. PMID: 28980524 Free PMC article.

9

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.

McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E, Muqit MMK, Brooks SP, Ganley IG. McWilliams TG, et al. Among authors: muqit mmk. Cell Metab. 2018 Feb 6;27(2):439-449.e5. doi: 10.1016/j.cmet.2017.12.008. Epub 2018 Jan 11. Cell Metab. 2018. PMID: 29337137 Free PMC article.

10

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.

McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK. McWilliams TG, et al. Among authors: muqit mmk. Open Biol. 2018 Nov 7;8(11):180108. doi: 10.1098/rsob.180108. Open Biol. 2018. PMID: 30404819 Free PMC article.

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