Flatt PR - Search Results

1

Cellular models for beta-cell function and diabetes gene therapy.

Green AD, Vasu S, Flatt PR. Green AD, et al. Among authors: flatt pr. Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.13012. Epub 2018 Jan 17. Acta Physiol (Oxf). 2018. PMID: 29226587 Review.

2

Secretion of glycated insulin from pancreatic beta-cells in diabetes represents a novel aspect of beta-cell dysfunction and glucose toxicity.

McKillop AM, Abdel-Wahab YH, Mooney MH, O'Harte FP, Flatt PR. McKillop AM, et al. Among authors: flatt pr. Diabetes Metab. 2002 Dec;28(6 Pt 2):3S61-9; discussion 3S108-12. Diabetes Metab. 2002. PMID: 12688635 Review.

3

Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells.

Liu HK, Green BD, Flatt PR, McClenaghan NH, McCluskey JT. Liu HK, et al. Among authors: flatt pr. Endocr Res. 2004 Feb;30(1):61-8. doi: 10.1081/erc-120028485. Endocr Res. 2004. PMID: 15098920

4

Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1.

Green BD, Liu HK, McCluskey JT, Duffy NA, O'Harte FP, McClenaghan NH, Flatt PR. Green BD, et al. Among authors: flatt pr. Diabetes Obes Metab. 2005 Sep;7(5):563-9. doi: 10.1111/j.1463-1326.2004.00430.x. Diabetes Obes Metab. 2005. PMID: 16050949

5

A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.

Green BD, Gault VA, O'Harte FP, Flatt PR. Green BD, et al. Among authors: flatt pr. Diabetes Obes Metab. 2005 Sep;7(5):595-604. doi: 10.1111/j.1463-1326.2004.00455.x. Diabetes Obes Metab. 2005. PMID: 16050953

6

Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage.

Patterson S, Flatt PR, McClenaghan NH. Patterson S, et al. Among authors: flatt pr. Biochim Biophys Acta. 2006 Jul;1760(7):1109-14. doi: 10.1016/j.bbagen.2006.03.012. Epub 2006 Apr 7. Biochim Biophys Acta. 2006. PMID: 16632205

7

Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice.

Green BD, Lavery KS, Irwin N, O'harte FP, Harriott P, Greer B, Bailey CJ, Flatt PR. Green BD, et al. Among authors: flatt pr. J Pharmacol Exp Ther. 2006 Aug;318(2):914-21. doi: 10.1124/jpet.105.097824. Epub 2006 Apr 28. J Pharmacol Exp Ther. 2006. PMID: 16648370

8

Nutrient regulation of pancreatic beta-cell function in diabetes: problems and potential solutions.

Flatt PR, Green BD. Flatt PR, et al. Biochem Soc Trans. 2006 Nov;34(Pt 5):774-8. doi: 10.1042/BST0340774. Biochem Soc Trans. 2006. PMID: 17052195

9

Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents.

Patterson S, Scullion SM, McCluskey JT, Flatt PR, McClenaghan NH. Patterson S, et al. Among authors: flatt pr. Diabetes Metab Res Rev. 2007 May;23(4):324-34. doi: 10.1002/dmrr.699. Diabetes Metab Res Rev. 2007. PMID: 17089371

10

Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase.

Patterson S, Flatt PR, McClenaghan NH. Patterson S, et al. Among authors: flatt pr. Pancreas. 2007 Jan;34(1):144-51. doi: 10.1097/01.mpa.0000240613.43345.51. Pancreas. 2007. PMID: 17198197

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