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Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.
Zou MF, Cao J, Abramyan AM, Kopajtic T, Zanettini C, Guthrie DA, Rais R, Slusher BS, Shi L, Loland CJ, Newman AH. Zou MF, et al. Among authors: abramyan am. J Med Chem. 2017 Dec 28;60(24):10172-10187. doi: 10.1021/acs.jmedchem.7b01454. Epub 2017 Dec 11. J Med Chem. 2017. PMID: 29227643 Free PMC article.
The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.
Quick M, Abramyan AM, Wiriyasermkul P, Weinstein H, Shi L, Javitch JA. Quick M, et al. Among authors: abramyan am. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7924-E7931. doi: 10.1073/pnas.1717444115. Epub 2018 Aug 6. Proc Natl Acad Sci U S A. 2018. PMID: 30082383 Free PMC article.
Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders.
Newman AH, Cao J, Keighron JD, Jordan CJ, Bi GH, Liang Y, Abramyan AM, Avelar AJ, Tschumi CW, Beckstead MJ, Shi L, Tanda G, Xi ZX. Newman AH, et al. Among authors: abramyan am. Neuropsychopharmacology. 2019 Jul;44(8):1435-1444. doi: 10.1038/s41386-019-0366-z. Epub 2019 Mar 11. Neuropsychopharmacology. 2019. PMID: 30858517 Free PMC article.
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