Webster SP - Search Results

1

11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, Forbes SJ, Webster SP, Iredale JP, Walker BR, Michailidou Z. Zou X, et al. Among authors: webster sp. Hepatology. 2018 Jun;67(6):2167-2181. doi: 10.1002/hep.29734. Epub 2018 Feb 22. Hepatology. 2018. PMID: 29251794 Free PMC article.

2

Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.

Webster SP, Ward P, Binnie M, Craigie E, McConnell KM, Sooy K, Vinter A, Seckl JR, Walker BR. Webster SP, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. doi: 10.1016/j.bmcl.2007.02.057. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17350260

3

11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity.

Hughes KA, Webster SP, Walker BR. Hughes KA, et al. Among authors: webster sp. Expert Opin Investig Drugs. 2008 Apr;17(4):481-96. doi: 10.1517/13543784.17.4.481. Expert Opin Investig Drugs. 2008. PMID: 18363514 Review.

4

Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.

Webster SP, Binnie M, McConnell KM, Sooy K, Ward P, Greaney MF, Vinter A, Pallin TD, Dyke HJ, Gill MI, Warner I, Seckl JR, Walker BR. Webster SP, et al. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3265-71. doi: 10.1016/j.bmcl.2010.04.055. Epub 2010 Apr 18. Bioorg Med Chem Lett. 2010. PMID: 20452767 Free PMC article.

5

Partial deficiency or short-term inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves cognitive function in aging mice.

Sooy K, Webster SP, Noble J, Binnie M, Walker BR, Seckl JR, Yau JL. Sooy K, et al. Among authors: webster sp. J Neurosci. 2010 Oct 13;30(41):13867-72. doi: 10.1523/JNEUROSCI.2783-10.2010. J Neurosci. 2010. PMID: 20943927 Free PMC article.

6

Optimal elevation of β-cell 11β-hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high-fat diet-induced β-cell failure.

Turban S, Liu X, Ramage L, Webster SP, Walker BR, Dunbar DR, Mullins JJ, Seckl JR, Morton NM. Turban S, et al. Among authors: webster sp. Diabetes. 2012 Mar;61(3):642-52. doi: 10.2337/db11-1054. Epub 2012 Feb 7. Diabetes. 2012. PMID: 22315313 Free PMC article.

7

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo.

Mitić T, Shave S, Semjonous N, McNae I, Cobice DF, Lavery GG, Webster SP, Hadoke PW, Walker BR, Andrew R. Mitić T, et al. Among authors: webster sp. Biochem Pharmacol. 2013 Jul 1;86(1):146-53. doi: 10.1016/j.bcp.2013.02.002. Epub 2013 Feb 13. Biochem Pharmacol. 2013. PMID: 23415904 Free PMC article.

8

Mass spectrometry imaging for dissecting steroid intracrinology within target tissues.

Cobice DF, Mackay CL, Goodwin RJ, McBride A, Langridge-Smith PR, Webster SP, Walker BR, Andrew R. Cobice DF, et al. Among authors: webster sp. Anal Chem. 2013 Dec 3;85(23):11576-84. doi: 10.1021/ac402777k. Epub 2013 Nov 19. Anal Chem. 2013. PMID: 24134553 Free PMC article.

9

Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.

Wilson K, Mole DJ, Binnie M, Homer NZ, Zheng X, Yard BA, Iredale JP, Auer M, Webster SP. Wilson K, et al. Among authors: webster sp. Protein Expr Purif. 2014 Mar;95(100):96-103. doi: 10.1016/j.pep.2013.11.015. Epub 2013 Dec 4. Protein Expr Purif. 2014. PMID: 24316190 Free PMC article.

10

Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities.

Navarrete-Vázquez G, Morales-Vilchis MG, Estrada-Soto S, Ramírez-Espinosa JJ, Hidalgo-Figueroa S, Nava-Zuazo C, Tlahuext H, Leon-Rivera I, Medina-Franco JL, López-Vallejo F, Webster SP, Binnie M, Ortiz-Andrade R, Moreno-Diaz H. Navarrete-Vázquez G, et al. Among authors: webster sp. Eur J Med Chem. 2014 Mar 3;74:179-86. doi: 10.1016/j.ejmech.2013.12.042. Epub 2014 Jan 8. Eur J Med Chem. 2014. PMID: 24462849

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