Chen L - Search Results

1

Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds.

Wang J, Yun D, Yao J, Fu W, Huang F, Chen L, Wei T, Yu C, Xu H, Zhou X, Huang Y, Wu J, Qiu P, Li W. Wang J, et al. Among authors: chen l. Eur J Med Chem. 2018 Jan 20;144:493-503. doi: 10.1016/j.ejmech.2017.12.043. Epub 2017 Dec 18. Eur J Med Chem. 2018. PMID: 29288946

2

Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-κB pathway inhibition.

Chen L, Li Q, Weng B, Wang J, Zhou Y, Cheng D, Sirirak T, Qiu P, Wu J. Chen L, et al. Eur J Med Chem. 2018 May 10;151:508-519. doi: 10.1016/j.ejmech.2018.03.051. Epub 2018 Apr 6. Eur J Med Chem. 2018. PMID: 29655083

3

Design, synthesis, and evaluation of chalcone analogues incorporate α,β-Unsaturated ketone functionality as anti-lung cancer agents via evoking ROS to induce pyroptosis.

Zhu M, Wang J, Xie J, Chen L, Wei X, Jiang X, Bao M, Qiu Y, Chen Q, Li W, Jiang C, Zhou X, Jiang L, Qiu P, Wu J. Zhu M, et al. Among authors: chen l, chen q. Eur J Med Chem. 2018 Sep 5;157:1395-1405. doi: 10.1016/j.ejmech.2018.08.072. Epub 2018 Aug 30. Eur J Med Chem. 2018. PMID: 30196062

4

Synthesis, biological evaluation, QSAR and molecular dynamics simulation studies of potential fibroblast growth factor receptor 1 inhibitors for the treatment of gastric cancer.

Ying S, Du X, Fu W, Yun D, Chen L, Cai Y, Xu Q, Wu J, Li W, Liang G. Ying S, et al. Among authors: chen l. Eur J Med Chem. 2017 Feb 15;127:885-899. doi: 10.1016/j.ejmech.2016.10.066. Epub 2016 Nov 1. Eur J Med Chem. 2017. PMID: 27829519

5

Design, synthesis, and evaluation of NDGA analogues as potential anti-ischemic stroke agents.

Huang L, Wang J, Chen L, Zhu M, Wu S, Chu S, Zheng Y, Fan Z, Zhang J, Li W, Chen D, Yang X, Wang S, Qiu P, Wu J. Huang L, et al. Among authors: chen l, chen d. Eur J Med Chem. 2018 Jan 1;143:1165-1173. doi: 10.1016/j.ejmech.2017.09.028. Epub 2017 Oct 16. Eur J Med Chem. 2018. PMID: 29126723

6

Design and optimize N-substituted EF24 as effective and low toxicity NF-κB inhibitor for lung cancer therapy via apoptosis-to-pyroptosis switch.

Chen L, Li Q, Zheng Z, Xie J, Lin X, Jiang C, Xu H, Wu X, Wu J, Zhang H. Chen L, et al. Chem Biol Drug Des. 2019 Jul;94(1):1368-1377. doi: 10.1111/cbdd.13514. Epub 2019 Apr 22. Chem Biol Drug Des. 2019. PMID: 30873716

7

Piperlongumine analogue L50377 induces pyroptosis via ROS mediated NF-κB suppression in non-small-cell lung cancer.

Li Q, Chen L, Dong Z, Zhao Y, Deng H, Wu J, Wu X, Li W. Li Q, et al. Among authors: chen l. Chem Biol Interact. 2019 Nov 1;313:108820. doi: 10.1016/j.cbi.2019.108820. Epub 2019 Sep 10. Chem Biol Interact. 2019. PMID: 31518571

8

The discovery of potent and stable short peptide FGFR1 antagonist for cancer therapy.

Wu J, Chen L, Chen L, Fan L, Wang Z, Dong Z, Chen Q, Wei T, Cai Y, Li W. Wu J, et al. Among authors: chen l, chen q. Eur J Pharm Sci. 2020 Feb 15;143:105179. doi: 10.1016/j.ejps.2019.105179. Epub 2019 Dec 10. Eur J Pharm Sci. 2020. PMID: 31841696

9

Rational design, synthesis, and pharmacological characterisation of dicarbonyl curcuminoid analogues with improved stability against lung cancer via ROS and ER stress mediated cell apoptosis and pyroptosis.

Wei T, Zheng Z, Wei X, Liu Y, Li W, Fang B, Yun D, Dong Z, Yi B, Li W, Wu X, Chen D, Chen L, Wu J. Wei T, et al. Among authors: chen l, chen d. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2357-2369. doi: 10.1080/14756366.2022.2116015. J Enzyme Inhib Med Chem. 2022. PMID: 36039017 Free PMC article.

10

Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-κB.

Chen J, Zhang L, Shu Y, Chen L, Zhu M, Yao S, Wang J, Wu J, Liang G, Wu H, Li W. Chen J, et al. Among authors: chen l. Biomed Res Int. 2017;2017:4751260. doi: 10.1155/2017/4751260. Epub 2017 Mar 20. Biomed Res Int. 2017. PMID: 28409156 Free PMC article.

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