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Novel Pyrimidines as Antitubercular Agents.
Inoyama D, Paget SD, Russo R, Kandasamy S, Kumar P, Singleton E, Occi J, Tuckman M, Zimmerman MD, Ho HP, Perryman AL, Dartois V, Connell N, Freundlich JS. Inoyama D, et al. Among authors: freundlich js. Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02063-17. doi: 10.1128/AAC.02063-17. Print 2018 Mar. Antimicrob Agents Chemother. 2018. PMID: 29311070 Free PMC article.
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
Wilson R, Kumar P, Parashar V, Vilchèze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, Shenai S, Colangeli R, Jacobs WR Jr, Neiditch MB, Kremer L, Alland D. Wilson R, et al. Among authors: freundlich js. Nat Chem Biol. 2013 Aug;9(8):499-506. doi: 10.1038/nchembio.1277. Epub 2013 Jun 16. Nat Chem Biol. 2013. PMID: 23770708 Free PMC article.
Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis.
Stec J, Vilchèze C, Lun S, Perryman AL, Wang X, Freundlich JS, Bishai W, Jacobs WR Jr, Kozikowski AP. Stec J, et al. Among authors: freundlich js. ChemMedChem. 2014 Nov;9(11):2528-37. doi: 10.1002/cmdc.201402255. Epub 2014 Aug 27. ChemMedChem. 2014. PMID: 25165007 Free PMC article.
Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein.
Al Olaby RR, Cocquerel L, Zemla A, Saas L, Dubuisson J, Vielmetter J, Marcotrigiano J, Khan AG, Vences Catalan F, Perryman AL, Freundlich JS, Forli S, Levy S, Balhorn R, Azzazy HM. Al Olaby RR, et al. Among authors: freundlich js. PLoS One. 2014 Oct 30;9(10):e111333. doi: 10.1371/journal.pone.0111333. eCollection 2014. PLoS One. 2014. PMID: 25357246 Free PMC article.
Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.
Ekins S, Madrid PB, Sarker M, Li SG, Mittal N, Kumar P, Wang X, Stratton TP, Zimmerman M, Talcott C, Bourbon P, Travers M, Yadav M, Freundlich JS. Ekins S, et al. Among authors: freundlich js. PLoS One. 2015 Oct 30;10(10):e0141076. doi: 10.1371/journal.pone.0141076. eCollection 2015. PLoS One. 2015. PMID: 26517557 Free PMC article.
92 results