Xu Y - Search Results

1

Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP₂).

Ha J, Xu Y, Kawano T, Hendon T, Baki L, Garai S, Papapetropoulos A, Thakur GA, Plant LD, Logothetis DE. Ha J, et al. Among authors: xu y. J Biol Chem. 2018 Mar 9;293(10):3546-3561. doi: 10.1074/jbc.RA117.001679. Epub 2018 Jan 9. J Biol Chem. 2018. PMID: 29317494 Free PMC article.

2

The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.

Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA. Xu Y, et al. J Biol Chem. 2020 Mar 13;295(11):3614-3634. doi: 10.1074/jbc.RA119.011527. Epub 2020 Jan 17. J Biol Chem. 2020. PMID: 31953327 Free PMC article.

3

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism.

Gazgalis D, Cantwell L, Xu Y, Thakur GA, Cui M, Guarnieri F, Logothetis DE. Gazgalis D, et al. Among authors: xu y. Int J Mol Sci. 2022 Sep 16;23(18):10820. doi: 10.3390/ijms231810820. Int J Mol Sci. 2022. PMID: 36142730 Free PMC article.

4

The Pharmacology of Two-Pore Domain Potassium Channels.

Kamuene JM, Xu Y, Plant LD. Kamuene JM, et al. Among authors: xu y. Handb Exp Pharmacol. 2021;267:417-443. doi: 10.1007/164_2021_462. Handb Exp Pharmacol. 2021. PMID: 33880623

5

Hypoxia inhibits the cardiac I _K1 current through SUMO targeting Kir2.1 activation by PIP₂.

Xu Y, Yang Y, Chandrashekar A, Gada KD, Masotti M, Baggetta AM, Connolly JG, Kawano T, Plant LD. Xu Y, et al. iScience. 2022 Aug 17;25(9):104969. doi: 10.1016/j.isci.2022.104969. eCollection 2022 Sep 16. iScience. 2022. PMID: 36060074 Free PMC article.

6

Building KCNQ1/KCNE1 channel models and probing their interactions by molecular-dynamics simulations.

Xu Y, Wang Y, Meng XY, Zhang M, Jiang M, Cui M, Tseng GN. Xu Y, et al. Biophys J. 2013 Dec 3;105(11):2461-73. doi: 10.1016/j.bpj.2013.09.058. Biophys J. 2013. PMID: 24314077 Free PMC article.

7

Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.

Xu Y, Wang Y, Zhang M, Jiang M, Rosenhouse-Dantsker A, Wassenaar T, Tseng GN. Xu Y, et al. Biophys J. 2015 Jan 6;108(1):62-75. doi: 10.1016/j.bpj.2014.10.059. Biophys J. 2015. PMID: 25564853 Free PMC article.

8

Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2.

Wang Y, Zhang M, Xu Y, Jiang M, Zankov DP, Cui M, Tseng GN. Wang Y, et al. Among authors: xu y. J Gen Physiol. 2012 Dec;140(6):653-69. doi: 10.1085/jgp.201210847. J Gen Physiol. 2012. PMID: 23183700 Free PMC article.

9

Predicting protein interactions by Brownian dynamics simulations.

Meng XY, Xu Y, Zhang HX, Mezei M, Cui M. Meng XY, et al. Among authors: xu y. J Biomed Biotechnol. 2012;2012:121034. doi: 10.1155/2012/121034. Epub 2012 Feb 15. J Biomed Biotechnol. 2012. PMID: 22500075 Free PMC article.

10

Understanding the microscopic mechanisms for LQT1 needs a global view of the I(Ks) channel.

Tseng GN, Xu Y. Tseng GN, et al. Among authors: xu y. Heart Rhythm. 2015 Feb;12(2):395-6. doi: 10.1016/j.hrthm.2014.11.008. Epub 2014 Nov 7. Heart Rhythm. 2015. PMID: 25460172 Free PMC article. No abstract available.

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