Filizola M - Search Results

1

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.

Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY. Hughes TET, et al. Among authors: filizola m. Nat Struct Mol Biol. 2018 Jan;25(1):53-60. doi: 10.1038/s41594-017-0009-1. Epub 2018 Jan 1. Nat Struct Mol Biol. 2018. PMID: 29323279 Free PMC article.

2

Enhancing Opioid Bioactivity Predictions through Integration of Ligand-Based and Structure-Based Drug Discovery Strategies with Transfer and Deep Learning Techniques.

Provasi D, Filizola M. Provasi D, et al. Among authors: filizola m. bioRxiv [Preprint]. 2023 Aug 7:2023.08.04.552065. doi: 10.1101/2023.08.04.552065. bioRxiv. 2023. Update in: J Phys Chem B. 2023 Dec 21;127(50):10691-10699. doi: 10.1021/acs.jpcb.3c05306 PMID: 37609329 Free PMC article. Updated. Preprint.

3

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.

Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D. Kruegel AC, et al. Among authors: filizola m. J Am Chem Soc. 2016 Jun 1;138(21):6754-64. doi: 10.1021/jacs.6b00360. Epub 2016 May 18. J Am Chem Soc. 2016. PMID: 27192616 Free PMC article.

4

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake.

Wardman JH, Gomes I, Bobeck EN, Stockert JA, Kapoor A, Bisignano P, Gupta A, Mezei M, Kumar S, Filizola M, Devi LA. Wardman JH, et al. Among authors: filizola m. Sci Signal. 2016 May 31;9(430):ra55. doi: 10.1126/scisignal.aac8035. Sci Signal. 2016. PMID: 27245612 Free PMC article.

5

Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity.

Kapoor A, Martinez-Rosell G, Provasi D, de Fabritiis G, Filizola M. Kapoor A, et al. Among authors: filizola m. Sci Rep. 2017 Sep 12;7(1):11255. doi: 10.1038/s41598-017-11483-8. Sci Rep. 2017. PMID: 28900175 Free PMC article.

6

Molecular mechanism of setron-mediated inhibition of full-length 5-HT_3A receptor.

Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S. Basak S, et al. Among authors: filizola m. Nat Commun. 2019 Jul 19;10(1):3225. doi: 10.1038/s41467-019-11142-8. Nat Commun. 2019. PMID: 31324772 Free PMC article.

7

Structure-based characterization of novel TRPV5 inhibitors.

Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC 3rd, Filizola M, Rohacs T, Moiseenkova-Bell VY. Hughes TE, et al. Among authors: filizola m. Elife. 2019 Oct 25;8:e49572. doi: 10.7554/eLife.49572. Elife. 2019. PMID: 31647410 Free PMC article.

8

Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of µ-Opioid Receptor.

Kapoor A, Provasi D, Filizola M. Kapoor A, et al. Among authors: filizola m. Mol Pharmacol. 2020 Oct;98(4):475-486. doi: 10.1124/mol.119.119339. Epub 2020 Jul 17. Mol Pharmacol. 2020. PMID: 32680919 Free PMC article.

9

High-resolution structures of multiple 5-HT_3AR-setron complexes reveal a novel mechanism of competitive inhibition.

Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S. Basak S, et al. Among authors: filizola m. Elife. 2020 Oct 16;9:e57870. doi: 10.7554/eLife.57870. Elife. 2020. PMID: 33063666 Free PMC article.

10

Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom's Alkaloids with Reported Antinociception In Vivo.

Zhou Y, Ramsey S, Provasi D, El Daibani A, Appourchaux K, Chakraborty S, Kapoor A, Che T, Majumdar S, Filizola M. Zhou Y, et al. Among authors: filizola m. Biochemistry. 2021 May 11;60(18):1420-1429. doi: 10.1021/acs.biochem.0c00658. Epub 2020 Dec 4. Biochemistry. 2021. PMID: 33274929 Free PMC article.

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