Huffman WF - Search Results

1

Novel vasopressin analogues that help define a minimum effective antagonist pharmacophore.

Huffman WF, Ali FE, Bryan WM, Callahan JF, Moore ML, Silvestri JS, Yim NC, Kinter LB, McDonald JE, Ashton-Shue D, et al. Huffman WF, et al. J Med Chem. 1985 Dec;28(12):1759-60. doi: 10.1021/jm00150a003. J Med Chem. 1985. PMID: 2933517 No abstract available.

2

Potent vasopressin antagonists lacking the proline residue at position 7.

Ali FE, Bryan W, Chang HL, Huffman WF, Moore ML, Heckman G, Kinter LB, McDonald J, Schmidt D, Shue D, et al. Ali FE, et al. Among authors: huffman wf. J Med Chem. 1986 Jun;29(6):984-8. doi: 10.1021/jm00156a015. J Med Chem. 1986. PMID: 2940368

3

Potent antagonists of vasopressin antidiuretic activity that lack the beta,beta-cyclopentamethylene-beta-mercaptopropionic acid substitution at position 1.

Yim NC, Moore ML, Huffman WF, Bryan HG, Chang HL, Kinter LB, Edwards R, Stassen FL, Schmidt D, Heckman G. Yim NC, et al. Among authors: huffman wf. J Med Chem. 1986 Dec;29(12):2425-6. doi: 10.1021/jm00162a001. J Med Chem. 1986. PMID: 2946863 No abstract available.

4

Potent vasopressin antagonists modified at the carboxy-terminal tripeptide tail.

Ali FE, Chang HL, Huffman WF, Heckman G, Kinter LB, Weidley EF, Edwards R, Schmidt D, Ashton-Shue D, Stassen FL. Ali FE, et al. Among authors: huffman wf. J Med Chem. 1987 Dec;30(12):2291-4. doi: 10.1021/jm00395a019. J Med Chem. 1987. PMID: 2960813

5

Design, synthesis, and biological activity of a peptide mimic of vasopressin.

Bryan WM, Hempel JC, Huffman WF, Marshall GR, Moore ML, Silvestri J, Stassen FL, Stefankiewicz JS, Sulat L, Webb RL. Bryan WM, et al. Among authors: huffman wf. J Med Chem. 1988 Apr;31(4):742-4. doi: 10.1021/jm00399a009. J Med Chem. 1988. PMID: 2965243

6

A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of gamma-turn mimetics into a model substrate.

Newlander KA, Callahan JF, Moore ML, Tomaszek TA Jr, Huffman WF. Newlander KA, et al. Among authors: huffman wf. J Med Chem. 1993 Aug 6;36(16):2321-31. doi: 10.1021/jm00068a008. J Med Chem. 1993. PMID: 8360876

7

A minor modification of residue 1 in potent vasopressin antagonists dramatically reduces agonist activity.

Huffman WF, Albrightson-Winslow C, Brickson B, Bryan HG, Caldwell N, Dytko G, Eggleston DS, Kinter LB, Moore ML, Newlander KA, et al. Huffman WF, et al. J Med Chem. 1989 Apr;32(4):880-4. doi: 10.1021/jm00124a025. J Med Chem. 1989. PMID: 2522994

8

Cyclic enkephalin analogues containing alpha-amino-beta-mercapto-beta,beta-pentamethylenepropionic acid at positions 2 or 5.

Bryan WM, Callahan JF, Codd EE, Lemieux C, Moore ML, Schiller PW, Walker RF, Huffman WF. Bryan WM, et al. Among authors: huffman wf. J Med Chem. 1989 Feb;32(2):302-4. doi: 10.1021/jm00122a005. J Med Chem. 1989. PMID: 2536436

9

Vasopressin antagonist analogs modified at position 7.

Moore ML, Greene H, Huffman WF, Stassen F, Stefankiewicz J, Sulat L, Heckman G, Schmidt D, Kinter L, McDonald J, et al. Moore ML, et al. Among authors: huffman wf. Int J Pept Protein Res. 1986 Oct;28(4):379-85. doi: 10.1111/j.1399-3011.1986.tb03269.x. Int J Pept Protein Res. 1986. PMID: 2947871

10

Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists.

Keenan RM, Miller WH, Kwon C, Ali FE, Callahan JF, Calvo RR, Hwang SM, Kopple KD, Peishoff CE, Samanen JM, Wong AS, Yuan CK, Huffman WF. Keenan RM, et al. Among authors: huffman wf. J Med Chem. 1997 Jul 18;40(15):2289-92. doi: 10.1021/jm970205r. J Med Chem. 1997. PMID: 9240343 No abstract available.

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