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Discovery of a novel potent GPR40 full agonist.
Meegalla SK, Huang H, Martin T, Xu J, Zhao S, Liu J, Hall M, Gunnet J, Wang Y, Rady B, Silva J, Otieno M, Arnoult E, Paul Lee S, Pocai A, Player MR. Meegalla SK, et al. Among authors: xu j. Bioorg Med Chem Lett. 2018 Feb 15;28(4):720-726. doi: 10.1016/j.bmcl.2018.01.013. Epub 2018 Jan 12. Bioorg Med Chem Lett. 2018. PMID: 29366647
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.
Xu G, Gaul MD, Kuo GH, Du F, Xu JZ, Wallace N, Hinke S, Kirchner T, Silva J, Huebert ND, Lee S, Murray W, Liang Y, Demarest K. Xu G, et al. Among authors: xu jz. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3446-3453. doi: 10.1016/j.bmcl.2018.09.025. Epub 2018 Sep 19. Bioorg Med Chem Lett. 2018. PMID: 30268701
GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action.
Lee SP, Qi J, Xu G, Rankin MM, Littrell J, Xu JZ, Bakaj I, Pocai A. Lee SP, et al. Among authors: xu jz, xu g. Front Endocrinol (Lausanne). 2021 May 14;12:652628. doi: 10.3389/fendo.2021.652628. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34054727 Free PMC article.
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists.
Shen L, Zhang Y, Wang A, Sieber-McMaster E, Chen X, Pelton P, Xu JZ, Yang M, Zhu P, Zhou L, Reuman M, Hu Z, Russell R, Gibbs AC, Ross H, Demarest K, Murray WV, Kuo GH. Shen L, et al. Bioorg Med Chem. 2008 Mar 15;16(6):3321-41. doi: 10.1016/j.bmc.2007.12.005. Epub 2007 Dec 8. Bioorg Med Chem. 2008. PMID: 18155554
Pharmacological profile of a novel, non-TZD PPARgamma agonist.
Chen X, Osborne MC, Rybczynski PJ, Zeck R, Yang M, Xu J, Zhou L, Cryan E, Tang Y, Demarest KT. Chen X, et al. Among authors: xu j. Diabetes Obes Metab. 2005 Sep;7(5):536-46. doi: 10.1111/j.1463-1326.2004.00425.x. Diabetes Obes Metab. 2005. PMID: 16050946
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