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The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-κB-mediated release of high-mobility group box-1.
Wang M, Gorasiya S, Antoine DJ, Sitapara RA, Wu W, Sharma L, Yang H, Ashby CR Jr, Vasudevan D, Zur M, Thomas DD, Mantell LL. Wang M, et al. Among authors: gorasiya s. Am J Respir Cell Mol Biol. 2015 Feb;52(2):171-82. doi: 10.1165/rcmb.2013-0544OC. Am J Respir Cell Mol Biol. 2015. PMID: 24992505 Free PMC article.
The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function.
Sitapara RA, Antoine DJ, Sharma L, Patel VS, Ashby CR Jr, Gorasiya S, Yang H, Zur M, Mantell LL. Sitapara RA, et al. Among authors: gorasiya s. Mol Med. 2014 Jun 19;20(1):238-47. doi: 10.2119/molmed.2013.00086. Mol Med. 2014. Retraction in: Mol Med. 2020 Dec 30;26(1):132. doi: 10.1186/s10020-020-00265-0 PMID: 24664237 Free PMC article. Retracted.
Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury.
Entezari M, Javdan M, Antoine DJ, Morrow DM, Sitapara RA, Patel V, Wang M, Sharma L, Gorasiya S, Zur M, Wu W, Li J, Yang H, Ashby CR, Thomas D, Wang H, Mantell LL. Entezari M, et al. Among authors: gorasiya s. Redox Biol. 2014 Jan 20;2:314-22. doi: 10.1016/j.redox.2014.01.013. eCollection 2014. Redox Biol. 2014. PMID: 24563849 Free PMC article.