Bottomley SP - Search Results

1

Probing the folding pathway of a consensus serpin using single tryptophan mutants.

Yang L, Irving JA, Dai W, Aguilar MI, Bottomley SP. Yang L, et al. Among authors: bottomley sp. Sci Rep. 2018 Feb 1;8(1):2121. doi: 10.1038/s41598-018-19567-9. Sci Rep. 2018. PMID: 29391487 Free PMC article.

2

Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition.

Cabrita LD, Dai W, Bottomley SP. Cabrita LD, et al. Among authors: bottomley sp. Biochemistry. 2004 Aug 3;43(30):9834-9. doi: 10.1021/bi0491346. Biochemistry. 2004. PMID: 15274637

3

The N terminus of the serpin, tengpin, functions to trap the metastable native state.

Zhang Q, Buckle AM, Law RH, Pearce MC, Cabrita LD, Lloyd GJ, Irving JA, Smith AI, Ruzyla K, Rossjohn J, Bottomley SP, Whisstock JC. Zhang Q, et al. Among authors: bottomley sp. EMBO Rep. 2007 Jul;8(7):658-63. doi: 10.1038/sj.embor.7400986. Epub 2007 Jun 8. EMBO Rep. 2007. PMID: 17557112 Free PMC article.

4

The roles of helix I and strand 5A in the folding, function and misfolding of α1-antitrypsin.

Knaupp AS, Keleher S, Yang L, Dai W, Bottomley SP, Pearce MC. Knaupp AS, et al. Among authors: bottomley sp. PLoS One. 2013;8(1):e54766. doi: 10.1371/journal.pone.0054766. Epub 2013 Jan 29. PLoS One. 2013. PMID: 23382962 Free PMC article.

5

Smoothing a rugged protein folding landscape by sequence-based redesign.

Porebski BT, Keleher S, Hollins JJ, Nickson AA, Marijanovic EM, Borg NA, Costa MG, Pearce MA, Dai W, Zhu L, Irving JA, Hoke DE, Kass I, Whisstock JC, Bottomley SP, Webb GI, McGowan S, Buckle AM. Porebski BT, et al. Among authors: bottomley sp. Sci Rep. 2016 Sep 26;6:33958. doi: 10.1038/srep33958. Sci Rep. 2016. PMID: 27667094 Free PMC article.

6

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.

Irving JA, Pike RN, Dai W, Brömme D, Worrall DM, Silverman GA, Coetzer TH, Dennison C, Bottomley SP, Whisstock JC. Irving JA, et al. Among authors: bottomley sp. Biochemistry. 2002 Apr 16;41(15):4998-5004. doi: 10.1021/bi0159985. Biochemistry. 2002. PMID: 11939796

7

Serpins: finely balanced conformational traps.

Pike RN, Bottomley SP, Irving JA, Bird PI, Whisstock JC. Pike RN, et al. Among authors: bottomley sp. IUBMB Life. 2002 Jul;54(1):1-7. doi: 10.1080/15216540213825. IUBMB Life. 2002. PMID: 12387568 Free article. Review.

8

The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment.

Irving JA, Cabrita LD, Rossjohn J, Pike RN, Bottomley SP, Whisstock JC. Irving JA, et al. Among authors: bottomley sp. Structure. 2003 Apr;11(4):387-97. doi: 10.1016/s0969-2126(03)00057-1. Structure. 2003. PMID: 12679017 Free article.

9

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.

Fulton KF, Buckle AM, Cabrita LD, Irving JA, Butcher RE, Smith I, Reeve S, Lesk AM, Bottomley SP, Rossjohn J, Whisstock JC. Fulton KF, et al. Among authors: bottomley sp. J Biol Chem. 2005 Mar 4;280(9):8435-42. doi: 10.1074/jbc.M410206200. Epub 2004 Dec 7. J Biol Chem. 2005. PMID: 15590653 Free article.

10

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.

McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan WT, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN, Whisstock JC. McGowan S, et al. Among authors: bottomley sp. EMBO J. 2006 Jul 12;25(13):3144-55. doi: 10.1038/sj.emboj.7601201. Epub 2006 Jun 29. EMBO J. 2006. PMID: 16810322 Free PMC article.

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